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Gene Review

Xrcc6  -  X-ray repair complementing defective...

Rattus norvegicus

Synonyms: G22p1, Ku70, Kup70
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Disease relevance of Xrcc6


High impact information on Xrcc6

  • These findings suggest that there are some defects in maintaining the levels of G22p1 and Xrcc5 proteins in the nuclei of LEC rat cells [2].
  • An analysis of fibroblasts from backcross rats showed that the deficiency in nuclear accumulation of G22p1 and Xrcc5 proteins is genetically linked to enhanced radiosensitivity [2].
  • DNA-PK is a heterotrimeric protein complex comprised of two components: a large catalytic subunit, Prkdc, with serine/threonine kinase activity and a DNA-targeting component, G22p1 and Xrcc5 [2].
  • G/GO treatment caused nuclear loss of both Ku70 and Ku80 in Wild cells and pcN-3 cells [3].

Biological context of Xrcc6


Anatomical context of Xrcc6


Other interactions of Xrcc6

  • These results suggest that nuclear translocation of G22p1 and Xrcc5 is important for the fast repair process of PLD in rat cells [4].

Analytical, diagnostic and therapeutic context of Xrcc6


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