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Gene Review:

Xrcc6 - X-ray repair complementing defective...

Rattus norvegicus

Synonyms: G22p1, Ku70, Kup70

Sugawara, T. et al., Okui, T. et al., Endoh, D. et al., Song, J.Y. et al.

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Disease relevance of Xrcc6

CONCLUSIONS: The temporal and spatial expression of Ku 70 corresponded to tolerance of the hippocampal CA1 neurons to subsequent ischemia, suggesting the involvement of Ku proteins in the development of neuronal tolerance after ischemic preconditioning [1].
Neuronal expression of the DNA repair protein Ku 70 after ischemic preconditioning corresponds to tolerance to global cerebral ischemia [1].

High impact information on Xrcc6

These findings suggest that there are some defects in maintaining the levels of G22p1 and Xrcc5 proteins in the nuclei of LEC rat cells [2].
An analysis of fibroblasts from backcross rats showed that the deficiency in nuclear accumulation of G22p1 and Xrcc5 proteins is genetically linked to enhanced radiosensitivity [2].
DNA-PK is a heterotrimeric protein complex comprised of two components: a large catalytic subunit, Prkdc, with serine/threonine kinase activity and a DNA-targeting component, G22p1 and Xrcc5 [2].
G/GO treatment caused nuclear loss of both Ku70 and Ku80 in Wild cells and pcN-3 cells [3].

Biological context of Xrcc6

During DNA damage, DNA repair proteins Ku70 and Ku80 prevent cell death, but severe DNA damage beyond the repair capacity of the DNA repair proteins triggers necrosis or apoptosis [3].

Anatomical context of Xrcc6

Although these proteins were observed mainly in the nuclei of human fibroblasts, approximately 80% of the intensities of immunofluorescence from both G22p1 and Xrcc5 was observed in the cytoplasm of rat fibroblasts [4].

Other interactions of Xrcc6

These results suggest that nuclear translocation of G22p1 and Xrcc5 is important for the fast repair process of PLD in rat cells [4].

Analytical, diagnostic and therapeutic context of Xrcc6

Immunohistochemistry showed virtually no constitutive expression of Ku proteins in CA1 neurons; however, ischemic preconditioning induced neuronal Ku 70 expression 1 to 3 days later [1].
Western blot confirmed an increase in Ku 70 in this region at the same time [1].

References

Neuronal expression of the DNA repair protein Ku 70 after ischemic preconditioning corresponds to tolerance to global cerebral ischemia. Sugawara, T., Noshita, N., Lewén, A., Kim, G.W., Chan, P.H. Stroke (2001) [Pubmed]
Deficiency in nuclear accumulation of G22p1 and Xrcc5 proteins in hyper-radiosensitive Long-Evans Cinnamon (LEC) rat cells after X irradiation. Okui, T., Endoh, D., Kon, Y., Hayashi, M. Radiat. Res. (2002) [Pubmed]
Role of NF-kappaB and DNA repair protein Ku on apoptosis in pancreatic acinar cells. Song, J.Y., Lim, J.W., Kim, H., Kim, K.H. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
Hypertonic treatment inhibits radiation-induced nuclear translocation of the Ku proteins G22p1 (Ku70) and Xrcc5 (Ku80) in rat fibroblasts. Endoh, D., Okui, T., Kon, Y., Hayashi, M. Radiat. Res. (2001) [Pubmed]

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AgaP_AGAP002690	Anopheles gambiae str. PEST
KU70	Arabidopsis thaliana
XRCC6	Bos taurus
cku-70	Caenorhabditis elegans
XRCC6	Canis lupus familiaris
xrcc6	Danio rerio
Irbp	Drosophila melanogaster
XRCC6	Gallus gallus
XRCC6	Homo sapiens
KLLA0C06226g	Kluyveromyces lactis NRRL Y-1140
XRCC6	Macaca mulatta
MGG_01512	Magnaporthe oryzae 70-15
Xrcc6	Mus musculus
NCU08290	Neurospora crassa OR74A
Os07g0184900	Oryza sativa Japonica Group
XRCC6	Pan troglodytes
YKU70	Saccharomyces cerevisiae S288c
pku70	Schizosaccharomyces pombe 972h-
xrcc6	Xenopus (Silurana) tropicalis

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