Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

PIP5K1 - phosphatidylinositol-4-phosphate 5-kinase 1

Arabidopsis thaliana

Synonyms: ATPIP5K1, ATPIPK1, PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE

Westergren, T. et al., Elge, S. et al., Mikami, K. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ATPIP5K1

A gene encoding phosphatidylinositol-4-phosphate 5-kinase is induced by water stress and abscisic acid in Arabidopsis thaliana [1].

High impact information on ATPIP5K1

Phosphorylation of AtPIP5K1 by protein kinase A is accompanied by a 40% inhibition of its catalytic activity [2].
We demonstrate here that the previously identified AtPIP5K1 gene from Arabidopsis thaliana encodes a PIPkin with dual substrate specificity in vitro, capable of phosphorylating PtdIns3P and PtdIns4P to PtdIns(3,4)P(2) and PtdIns(4,5)P(2) respectively [2].

Analytical, diagnostic and therapeutic context of ATPIP5K1

Enzymatic dissection of lipid headgroups revealed that AtP5K1-directed synthesis of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 proceeds via 5-phosphorylation of precursors [3].

References

A gene encoding phosphatidylinositol-4-phosphate 5-kinase is induced by water stress and abscisic acid in Arabidopsis thaliana. Mikami, K., Katagiri, T., Iuchi, S., Yamaguchi-Shinozaki, K., Shinozaki, K. Plant J. (1998) [Pubmed]
AtPIP5K1, an Arabidopsis thaliana phosphatidylinositol phosphate kinase, synthesizes PtdIns(3,4)P(2) and PtdIns(4,5)P(2) in vitro and is inhibited by phosphorylation. Westergren, T., Dove, S.K., Sommarin, M., Pical, C. Biochem. J. (2001) [Pubmed]
An Arabidopsis inositol phospholipid kinase strongly expressed in procambial cells: synthesis of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 in insect cells by 5-phosphorylation of precursors. Elge, S., Brearley, C., Xia, H.J., Kehr, J., Xue, H.W., Mueller-Roeber, B. Plant J. (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

PIP5K2	Arabidopsis thaliana
Os03g0705300	Oryza sativa Japonica Group

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.