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Gene Review

HORMAD1  -  HORMA domain containing 1

Homo sapiens

Synonyms: CT46, Cancer/testis antigen 46, DKFZP434A1315, HORMA domain-containing protein 1, NOHMA, ...
 
 
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Disease relevance of HORMAD1

  • Identification of CT46/HORMAD1, an immunogenic cancer/testis antigen encoding a putative meiosis-related protein [1].
  • The CT46/HORMAD1 gene was expressed in 31% (34/109) of the carcinomas examined, with 11% (12/109) showing expression levels >10% of the testicular level of expression [1].
 

High impact information on HORMAD1

  • One of these, CT46/HORMAD1, is expressed strongly in testis and weakly in placenta; the highest level of expression in other tissues is <1% of testicular expression [1].
  • CT46/HORMAD1 is a single-copy gene on chromosome 1q21.3, encoding a putative protein of 394 aa [1].
  • Restricted germ cell expression of a gene encoding a novel mammalian HORMA domain-containing protein [2].
  • HORMA-domain containing proteins are involved in cell cycle regulation by interactions with chromatin [2].
  • Nohma expression can be detected postnatally in male, and prenatally in female gonads, but shows a sexually dimorphic expression in adult gonads [2].
 

Biological context of HORMAD1

  • The expression pattern of Nohma suggests that it may be a critical regulatory protein in germ cell meiosis [2].

References

  1. Identification of CT46/HORMAD1, an immunogenic cancer/testis antigen encoding a putative meiosis-related protein. Chen, Y.T., Venditti, C.A., Theiler, G., Stevenson, B.J., Iseli, C., Gure, A.O., Jongeneel, C.V., Old, L.J., Simpson, A.J. Cancer Immun. (2005) [Pubmed]
  2. Restricted germ cell expression of a gene encoding a novel mammalian HORMA domain-containing protein. Pangas, S.A., Yan, W., Matzuk, M.M., Rajkovic, A. Gene Expr. Patterns (2004) [Pubmed]
 
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