Disease relevance of HORMAD1

• Identification of CT46/HORMAD1, an immunogenic cancer/testis antigen encoding a putative meiosis-related protein [1].
• The CT46/HORMAD1 gene was expressed in 31% (34/109) of the carcinomas examined, with 11% (12/109) showing expression levels >10% of the testicular level of expression [1].

High impact information on HORMAD1

• One of these, CT46/HORMAD1, is expressed strongly in testis and weakly in placenta; the highest level of expression in other tissues is <1% of testicular expression [1].
• CT46/HORMAD1 is a single-copy gene on chromosome 1q21.3, encoding a putative protein of 394 aa [1].
• Restricted germ cell expression of a gene encoding a novel mammalian HORMA domain-containing protein [2].
• HORMA-domain containing proteins are involved in cell cycle regulation by interactions with chromatin [2].
• Nohma expression can be detected postnatally in male, and prenatally in female gonads, but shows a sexually dimorphic expression in adult gonads [2].

Biological context of HORMAD1

• The expression pattern of Nohma suggests that it may be a critical regulatory protein in germ cell meiosis [2].

References