High impact information on AIN1

• Epistasis analysis placed XRN4/EIN5/AIN1 downstream of CTR1 and upstream of EBF1/2 [1].
• The Exoribonuclease XRN4 Is a Component of the Ethylene Response Pathway in Arabidopsis [1].
• The identification of XRN4 as an integral new component in ethylene signaling adds RNA degradation as another posttranscriptional process that modulates the perception of this plant hormone [1].
• XRN4 does not appear to regulate ethylene signaling via an RNA-INDUCED SILENCING COMPLEX-based RNA silencing mechanism but acts by independent means [1].
• Although a role for XRN4 in RNA silencing of certain transgenes has been reported, xrn4 mutant plants were found to lack any apparent visible phenotype [1].

Biological context of AIN1

• When both XRN4 and the RdRp were mutated, the plants accumulated decapped transgene mRNA [2].

Other interactions of AIN1

• Here, we show that RdRp-dependent transgene silencing in Arabidopsis was caused by mutation of XRN4, which is a ribonuclease (RNase) implicated in mRNA turnover by means of decapping and 5'-3' exonucleolysis [2].

References