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Gene Review

RNS1  -  ribonuclease 1

Arabidopsis thaliana

Synonyms: ATRNS1, RIBONUCLEASE 1, T17M13.16, T17M13_16
 
 
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Disease relevance of RNS1

 

High impact information on RNS1

  • Both miRNA and RNA silencing pathways require participation of DICER-LIKE (DCL) ribonuclease III-like enzymes [2].
  • Small interfering RNAs (siRNAs) and microRNAs (miRNAs) are processed by the ribonuclease Dicer from distinct precursors, double-stranded RNA (dsRNA) and hairpin RNAs, respectively, although either may guide RNA silencing via a similar complex [3].
  • However, two other Pi starvation-responsive genes, AtIPS1 and AtRNS1, are induced more slowly in siz1 seedlings by Pi limitation [4].
  • To address these questions, we have investigated the RNS2 gene, which encodes an S-like RNase (RNS2) of Arabidopsis [5].
  • They are processed from longer precursor RNAs that fold into stem-loop structures by the ribonuclease Dicer and are thought to regulate gene expression by base pairing with RNAs of protein-coding genes [6].
 

Biological context of RNS1

  • In contrast to what occurs during P(i) starvation, both RNS1 and RNS3 are modestly induced during senescence, indicating that the two stimuli could trigger different signal transduction pathways [7].
  • Amino acid sequence, genomic structure and phylogenetic analyses indicated that AhSL28 is most similar to RNS2, an S-like RNase from Arabidopsis thaliana and formed a distinct subclass together with several other S-like RNases within the S-RNase superfamily [8].
  • Map-based cloning of AHG2 revealed that this gene encodes a poly(A)-specific ribonuclease (AtPARN) that is presumed to function in mRNA degradation [9].
  • Here, using reverse transcription PCR and ribonuclease protection analysis, we demonstrate that, in addition to the full-length CGS transcript, a deleted form exists in Arabidopsis [10].
  • Ribonuclease protection showed tETR mRNA was undetectable in unripe fruit or pre-senescent flowers, increased in abundance during the early stages of ripening, flower senescence, and in abscission zones, and was greatly reduced in fruit of ripening mutants deficient in ethylene synthesis or response [11].
 

Associations of RNS1 with chemical compounds

 

Other interactions of RNS1

  • These specific antibodies also demonstrated that RNS1 is secreted, whereas RNS2 is intracellular [15].
  • The RNS1 gene is sharply induced during starvation for P(i), an effect specific among the major macronutrients, whereas RNS3 transcript levels remain relatively constant [7].
  • The corresponding cDNA clone VRN1, encoding an S-like RNase of V. carteri, is the first T(2)/S-like RNase to be cloned from green algae [16].
  • Ribonuclease protection experiments showed further that this negative regulation is confined almost exclusively to the shortest, most abundant PHYA transcript, and occurs predominantly in shoots [17].
 

Analytical, diagnostic and therapeutic context of RNS1

References

  1. Spinach CSP41, an mRNA-binding protein and ribonuclease, is homologous to nucleotide-sugar epimerases and hydroxysteroid dehydrogenases. Baker, M.E., Grundy, W.N., Elkan, C.P. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  2. Ectopic DICER-LIKE1 expression in P1/HC-Pro Arabidopsis rescues phenotypic anomalies but not defects in microRNA and silencing pathways. Mlotshwa, S., Schauer, S.E., Smith, T.H., Mallory, A.C., Herr, J.M., Roth, B., Merchant, D.S., Ray, A., Bowman, L.H., Vance, V.B. Plant Cell (2005) [Pubmed]
  3. Viral virulence protein suppresses RNA silencing-mediated defense but upregulates the role of microrna in host gene expression. Chen, J., Li, W.X., Xie, D., Peng, J.R., Ding, S.W. Plant Cell (2004) [Pubmed]
  4. The Arabidopsis SUMO E3 ligase SIZ1 controls phosphate deficiency responses. Miura, K., Rus, A., Sharkhuu, A., Yokoi, S., Karthikeyan, A.S., Raghothama, K.G., Baek, D., Koo, Y.D., Jin, J.B., Bressan, R.A., Yun, D.J., Hasegawa, P.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  5. RNS2: a senescence-associated RNase of Arabidopsis that diverged from the S-RNases before speciation. Taylor, C.B., Bariola, P.A., delCardayré, S.B., Raines, R.T., Green, P.J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  6. CARPEL FACTORY, a Dicer homolog, and HEN1, a novel protein, act in microRNA metabolism in Arabidopsis thaliana. Park, W., Li, J., Song, R., Messing, J., Chen, X. Curr. Biol. (2002) [Pubmed]
  7. The Arabidopsis ribonuclease gene RNS1 is tightly controlled in response to phosphate limitation. Bariola, P.A., Howard, C.J., Taylor, C.B., Verburg, M.T., Jaglan, V.D., Green, P.J. Plant J. (1994) [Pubmed]
  8. AhSL28, a senescence- and phosphate starvation-induced S-like RNase gene in Antirrhinum. Liang, L., Lai, Z., Ma, W., Zhang, Y., Xue, Y. Biochim. Biophys. Acta (2002) [Pubmed]
  9. Analysis of ABA hypersensitive germination2 revealed the pivotal functions of PARN in stress response in Arabidopsis. Nishimura, N., Kitahata, N., Seki, M., Narusaka, Y., Narusaka, M., Kuromori, T., Asami, T., Shinozaki, K., Hirayama, T. Plant J. (2005) [Pubmed]
  10. An in vivo internal deletion in the N-terminus region of Arabidopsis cystathionine gamma-synthase results in CGS expression that is insensitive to methionine. Hacham, Y., Schuster, G., Amir, R. Plant J. (2006) [Pubmed]
  11. Ethylene receptor expression is regulated during fruit ripening, flower senescence and abscission. Payton, S., Fray, R.G., Brown, S., Grierson, D. Plant Mol. Biol. (1996) [Pubmed]
  12. Local and systemic wound-induction of RNase and nuclease activities in Arabidopsis: RNS1 as a marker for a JA-independent systemic signaling pathway. LeBrasseur, N.D., MacIntosh, G.C., Pérez-Amador, M.A., Saitoh, M., Green, P.J. Plant J. (2002) [Pubmed]
  13. Nuclear-organelle interactions: the immutans variegation mutant of Arabidopsis is plastid autonomous and impaired in carotenoid biosynthesis. Wetzel, C.M., Jiang, C.Z., Meehan, L.J., Voytas, D.F., Rodermel, S.R. Plant J. (1994) [Pubmed]
  14. Oxygen control of ethylene biosynthesis during seed development in Arabidopsis thaliana (L.) Heynh. Ramonell, K.M., McClure, G., Musgrave, M.E. Plant Cell Environ. (2002) [Pubmed]
  15. Regulation of S-like ribonuclease levels in Arabidopsis. Antisense inhibition of RNS1 or RNS2 elevates anthocyanin accumulation. Bariola, P.A., MacIntosh, G.C., Green, P.J. Plant Physiol. (1999) [Pubmed]
  16. A senescence-associated S-like RNase in the multicellular green alga Volvox carteri. Shimizu, T., Inoue, T., Shiraishi, H. Gene (2001) [Pubmed]
  17. Both phyA and phyB mediate light-imposed repression of PHYA gene expression in Arabidopsis. Cantón, F.R., Quail, P.H. Plant Physiol. (1999) [Pubmed]
  18. Molecular cloning of cDNAs encoding ribonuclease-related proteins in Nicotiana glutinosa leaves, as induced in response to wounding or to TMV-infection. Kurata, N., Kariu, T., Kawano, S., Kimura, M. Biosci. Biotechnol. Biochem. (2002) [Pubmed]
 
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