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Gene Review

C2orf40  -  chromosome 2 open reading frame 40

Homo sapiens

Synonyms: Augurin, ECRG4, Esophageal cancer-related gene 4 protein, UNQ761/PRO1508, augurin
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Disease relevance of C2orf40


High impact information on C2orf40

  • Gene fragments selectively amplified in osteoarthritic cartilage by cDNA representational difference analysis included YKL-39 and the oesophageal-cancer-related-gene-4 (ECRG4) [2].
  • Expression of ECRG4, a novel esophageal cancer-related gene, downregulated by CpG island hypermethylation in human esophageal squamous cell carcinoma [1].
  • METHODS: A pair of primers was designed to amplify a 220 bp fragment, which contains 16 CpG sites in the core promoter region of the ECRG 4 gene [1].

Analytical, diagnostic and therapeutic context of C2orf40

  • The expression level of the ECRG 4 gene in these samples was examined by RT-PCR [1].


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