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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

C2orf40  -  chromosome 2 open reading frame 40

Homo sapiens

Synonyms: Augurin, ECRG4, Esophageal cancer-related gene 4 protein, UNQ761/PRO1508, augurin
 
 
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Disease relevance of C2orf40

 

High impact information on C2orf40

  • Gene fragments selectively amplified in osteoarthritic cartilage by cDNA representational difference analysis included YKL-39 and the oesophageal-cancer-related-gene-4 (ECRG4) [2].
  • Expression of ECRG4, a novel esophageal cancer-related gene, downregulated by CpG island hypermethylation in human esophageal squamous cell carcinoma [1].
  • METHODS: A pair of primers was designed to amplify a 220 bp fragment, which contains 16 CpG sites in the core promoter region of the ECRG 4 gene [1].
 

Analytical, diagnostic and therapeutic context of C2orf40

  • The expression level of the ECRG 4 gene in these samples was examined by RT-PCR [1].

References

  1. Expression of ECRG4, a novel esophageal cancer-related gene, downregulated by CpG island hypermethylation in human esophageal squamous cell carcinoma. Yue, C.M., Deng, D.J., Bi, M.X., Guo, L.P., Lu, S.H. World J. Gastroenterol. (2003) [Pubmed]
  2. Enhanced expression of the human chitinase 3-like 2 gene (YKL-39) but not chitinase 3-like 1 gene (YKL-40) in osteoarthritic cartilage. Steck, E., Breit, S., Breusch, S.J., Axt, M., Richter, W. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
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