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Gene Review

CHI3L2  -  chitinase 3-like 2

Homo sapiens

Synonyms: CHIL2, Chitinase-3-like protein 2, Chondrocyte protein 39, YKL-39, YKL39
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Disease relevance of CHI3L2


High impact information on CHI3L2


Biological context of CHI3L2


Anatomical context of CHI3L2

  • T cell proliferation response to YKL-39 was analyzed using the 3H-thymidine incorporation assay [7].

Other interactions of CHI3L2

  • Enhanced levels of YKL-40 may, therefore, be derived from synovial cells while modulation of YKL-39 and collagen 2 expression reflected the cartilage metabolism in response to degradation [1].
  • Gene fragments selectively amplified in osteoarthritic cartilage by cDNA representational difference analysis included YKL-39 and the oesophageal-cancer-related-gene-4 (ECRG4) [1].
  • Recognition of YKL-39, a human cartilage related protein, as a target antigen in patients with rheumatoid arthritis [6].

Analytical, diagnostic and therapeutic context of CHI3L2


  1. Enhanced expression of the human chitinase 3-like 2 gene (YKL-39) but not chitinase 3-like 1 gene (YKL-40) in osteoarthritic cartilage. Steck, E., Breit, S., Breusch, S.J., Axt, M., Richter, W. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  2. YKL-39 (chitinase 3-like protein 2), but not YKL-40 (chitinase 3-like protein 1), is up regulated in osteoarthritic chondrocytes. Knorr, T., Obermayr, F., Bartnik, E., Zien, A., Aigner, T. Ann. Rheum. Dis. (2003) [Pubmed]
  3. YKL-39, a human cartilage-related protein, induces arthritis in mice. Sakata, M., Masuko-Hongo, K., Tsuruha, J., Sekine, T., Nakamura, H., Takigawa, M., Nishioka, K., Kato, T. Clinical and experimental rheumatology. (2002) [Pubmed]
  4. The prevalence of autoantibodies against cartilage intermediate layer protein, YKL-39, osteopontin, and cyclic citrullinated peptide in patients with early-stage knee osteoarthritis: evidence of a variety of autoimmune processes. Du, H., Masuko-Hongo, K., Nakamura, H., Xiang, Y., Bao, C.D., Wang, X.D., Chen, S.L., Nishioka, K., Kato, T. Rheumatol. Int. (2005) [Pubmed]
  5. Isolation and sequence of a novel human chondrocyte protein related to mammalian members of the chitinase protein family. Hu, B., Trinh, K., Figueira, W.F., Price, P.A. J. Biol. Chem. (1996) [Pubmed]
  6. Recognition of YKL-39, a human cartilage related protein, as a target antigen in patients with rheumatoid arthritis. Sekine, T., Masuko-Hongo, K., Matsui, T., Asahara, H., Takigawa, M., Nishioka, K., Kato, T. Ann. Rheum. Dis. (2001) [Pubmed]
  7. Autoimmunity against YKL-39, a human cartilage derived protein, in patients with osteoarthritis. Tsuruha, J., Masuko-Hongo, K., Kato, T., Sakata, M., Nakamura, H., Sekine, T., Takigawa, M., Nishioka, K. J. Rheumatol. (2002) [Pubmed]
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