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Disease relevance of Hypogonadism


Psychiatry related information on Hypogonadism


High impact information on Hypogonadism


Chemical compound and disease context of Hypogonadism


Biological context of Hypogonadism


Anatomical context of Hypogonadism


Gene context of Hypogonadism


Analytical, diagnostic and therapeutic context of Hypogonadism


  1. Kallmann syndrome gene on the X and Y chromosomes: implications for evolutionary divergence of human sex chromosomes. Incerti, B., Guioli, S., Pragliola, A., Zanaria, E., Borsani, G., Tonlorenzi, R., Bardoni, B., Franco, B., Wheeler, D., Ballabio, A. Nat. Genet. (1992) [Pubmed]
  2. Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene. Layman, L.C., Lee, E.J., Peak, D.B., Namnoum, A.B., Vu, K.V., van Lingen, B.L., Gray, M.R., McDonough, P.G., Reindollar, R.H., Jameson, J.L. N. Engl. J. Med. (1997) [Pubmed]
  3. Prolactin-screening tumors and hypogonadism in 22 men. Carter, J.N., Tyson, J.E., Tolis, G., Van Vliet, S., Faiman, C., Friesen, H.G. N. Engl. J. Med. (1978) [Pubmed]
  4. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Papanikolaou, G., Samuels, M.E., Ludwig, E.H., MacDonald, M.L., Franchini, P.L., Dubé, M.P., Andres, L., MacFarlane, J., Sakellaropoulos, N., Politou, M., Nemeth, E., Thompson, J., Risler, J.K., Zaborowska, C., Babakaiff, R., Radomski, C.C., Pape, T.D., Davidas, O., Christakis, J., Brissot, P., Lockitch, G., Ganz, T., Hayden, M.R., Goldberg, Y.P. Nat. Genet. (2004) [Pubmed]
  5. Parathyroid hormone for the prevention of bone loss induced by estrogen deficiency. Finkelstein, J.S., Klibanski, A., Schaefer, E.H., Hornstein, M.D., Schiff, I., Neer, R.M. N. Engl. J. Med. (1994) [Pubmed]
  6. Mutation in Rab3 GTPase-activating protein (RAB3GAP) noncatalytic subunit in a kindred with Martsolf syndrome. Aligianis, I.A., Morgan, N.V., Mione, M., Johnson, C.A., Rosser, E., Hennekam, R.C., Adams, G., Trembath, R.C., Pilz, D.T., Stoodley, N., Moore, A.T., Wilson, S., Maher, E.R. Am. J. Hum. Genet. (2006) [Pubmed]
  7. Two novel mutations in the gonadotropin-releasing hormone receptor gene in Brazilian patients with hypogonadotropic hypogonadism and normal olfaction. Costa, E.M., Bedecarrats, G.Y., Mendonca, B.B., Arnhold, I.J., Kaiser, U.B., Latronico, A.C. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  8. Correcting impotence in the male dialysis patient: experience with testosterone replacement and vacuum tumescence therapy. Lawrence, I.G., Price, D.E., Howlett, T.A., Harris, K.P., Feehally, J., Walls, J. Am. J. Kidney Dis. (1998) [Pubmed]
  9. Endocrine screening for sexual dysfunction using free testosterone determinations. Govier, F.E., McClure, R.D., Kramer-Levien, D. J. Urol. (1996) [Pubmed]
  10. Pathogenesis of vertebral crush fractures in men. Baillie, S.P., Davison, C.E., Johnson, F.J., Francis, R.M. Age and ageing. (1992) [Pubmed]
  11. FSH directly regulates bone mass. Sun, L., Peng, Y., Sharrow, A.C., Iqbal, J., Zhang, Z., Papachristou, D.J., Zaidi, S., Zhu, L.L., Yaroslavskiy, B.B., Zhou, H., Zallone, A., Sairam, M.R., Kumar, T.R., Bo, W., Braun, J., Cardoso-Landa, L., Schaffler, M.B., Moonga, B.S., Blair, H.C., Zaidi, M. Cell (2006) [Pubmed]
  12. Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. St John, M.A., Tao, W., Fei, X., Fukumoto, R., Carcangiu, M.L., Brownstein, D.G., Parlow, A.F., McGrath, J., Xu, T. Nat. Genet. (1999) [Pubmed]
  13. Hypogonadotropic hypogonadism in a female caused by an X-linked recessive mutation in the DAX1 gene. Merke, D.P., Tajima, T., Baron, J., Cutler, G.B. N. Engl. J. Med. (1999) [Pubmed]
  14. Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism. Layman, L.C., Cohen, D.P., Jin, M., Xie, J., Li, Z., Reindollar, R.H., Bolbolan, S., Bick, D.P., Sherins, R.R., Duck, L.W., Musgrove, L.C., Sellers, J.C., Neill, J.D. Nat. Genet. (1998) [Pubmed]
  15. A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor. de Roux, N., Young, J., Misrahi, M., Genet, R., Chanson, P., Schaison, G., Milgrom, E. N. Engl. J. Med. (1997) [Pubmed]
  16. Adult-onset idiopathic hypogonadotropic hypogonadism--a treatable form of male infertility. Nachtigall, L.B., Boepple, P.A., Pralong, F.P., Crowley, W.F. N. Engl. J. Med. (1997) [Pubmed]
  17. Brief report: melatonin-related hypogonadotropic hypogonadism. Puig-Domingo, M., Webb, S.M., Serrano, J., Peinado, M.A., Corcoy, R., Ruscalleda, J., Reiter, R.J., de Leiva, A. N. Engl. J. Med. (1992) [Pubmed]
  18. Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. Muscatelli, F., Strom, T.M., Walker, A.P., Zanaria, E., Récan, D., Meindl, A., Bardoni, B., Guioli, S., Zehetner, G., Rabl, W. Nature (1994) [Pubmed]
  19. The decline of androgen levels in elderly men and its clinical and therapeutic implications. Kaufman, J.M., Vermeulen, A. Endocr. Rev. (2005) [Pubmed]
  20. Association of hypogonadism and estradiol levels with bone mineral density in elderly men from the Framingham study. Amin, S., Zhang, Y., Sawin, C.T., Evans, S.R., Hannan, M.T., Kiel, D.P., Wilson, P.W., Felson, D.T. Ann. Intern. Med. (2000) [Pubmed]
  21. Long-term administration of gonadotropin-releasing hormone in men with idiopathic hypogonadotropic hypogonadism. A model for studies of the hormone's physiologic effects. Spratt, D.I., Finkelstein, J.S., O'Dea, L.S., Badger, T.M., Rao, P.N., Campbell, J.D., Crowley, W.F. Ann. Intern. Med. (1986) [Pubmed]
  22. Hemochromatosis, hypogonadism, testosterone, and erythropoiesis. O'Hare, J.A., Rolla, A.P. Ann. Intern. Med. (1985) [Pubmed]
  23. Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2. Matsumoto, S., Yamazaki, C., Masumoto, K.H., Nagano, M., Naito, M., Soga, T., Hiyama, H., Matsumoto, M., Takasaki, J., Kamohara, M., Matsuo, A., Ishii, H., Kobori, M., Katoh, M., Matsushime, H., Furuichi, K., Shigeyoshi, Y. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  24. X-linked adrenal hypoplasia congenita is caused by abnormal nuclear localization of the DAX-1 protein. Lehmann, S.G., Lalli, E., Sassone-Corsi, P. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  25. Intrahypothalamic injection of a cell line secreting gonadotropin-releasing hormone results in cellular differentiation and reversal of hypogonadism in mutant mice. Silverman, A.J., Roberts, J.L., Dong, K.W., Miller, G.M., Gibson, M.J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  26. Parallel regulation of membrane trafficking and dominant-negative effects by misrouted gonadotropin-releasing hormone receptor mutants. Knollman, P.E., Janovick, J.A., Brothers, S.P., Conn, P.M. J. Biol. Chem. (2005) [Pubmed]
  27. The development of astrocytes immunoreactive for glial fibrillary acidic protein in the mediobasal hypothalamus of hypogonadal mice. McQueen, J.K., Wilson, H. Mol. Cell. Neurosci. (1994) [Pubmed]
  28. Hypogonadism, quadriceps weakness, and exercise intolerance in chronic obstructive pulmonary disease. Van Vliet, M., Spruit, M.A., Verleden, G., Kasran, A., Van Herck, E., Pitta, F., Bouillon, R., Decramer, M. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  29. The gene responsible for adrenal hypoplasia congenita, DAX-1, encodes a nuclear hormone receptor that defines a new class within the superfamily. Burris, T.P., Guo, W., McCabe, E.R. Recent Prog. Horm. Res. (1996) [Pubmed]
  30. Ontogeny of GnRH and olfactory neuronal systems in man: novel insights from the investigation of inherited forms of Kallmann's syndrome. González-Martínez, D., Hu, Y., Bouloux, P.M. Frontiers in neuroendocrinology. (2004) [Pubmed]
  31. Aromatase (Cyp19) expression is up-regulated by targeted disruption of Dax1. Wang, Z.J., Jeffs, B., Ito, M., Achermann, J.C., Yu, R.N., Hales, D.B., Jameson, J.L. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  32. Genetic abnormalities and juvenile hemochromatosis: mutations of the HJV gene encoding hemojuvelin. Lee, P.L., Beutler, E., Rao, S.V., Barton, J.C. Blood (2004) [Pubmed]
  33. Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice. Koomen, M., Cheng, N.C., van de Vrugt, H.J., Godthelp, B.C., van der Valk, M.A., Oostra, A.B., Zdzienicka, M.Z., Joenje, H., Arwert, F. Hum. Mol. Genet. (2002) [Pubmed]
  34. Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia. Wong, J.C., Alon, N., Mckerlie, C., Huang, J.R., Meyn, M.S., Buchwald, M. Hum. Mol. Genet. (2003) [Pubmed]
  35. Induction of puberty in men by long-term pulsatile administration of low-dose gonadotropin-releasing hormone. Hoffman, A.R., Crowley, W.F. N. Engl. J. Med. (1982) [Pubmed]
  36. Monoamines and neurosteroids in sexual function during induced hypogonadism in healthy men. Bloch, M., Rubinow, D.R., Berlin, K., Kevala, K.R., Kim, H.Y., Schmidt, P.J. Arch. Gen. Psychiatry (2006) [Pubmed]
  37. Physiologic testosterone levels in normal men suppress high-density lipoprotein cholesterol levels. Bagatell, C.J., Knopp, R.H., Vale, W.W., Rivier, J.E., Bremner, W.J. Ann. Intern. Med. (1992) [Pubmed]
  38. Treatment of primary hypogonadism in men by the transdermal administration of testosterone. Findlay, J.C., Place, V., Snyder, P.J. J. Clin. Endocrinol. Metab. (1989) [Pubmed]
  39. Serum inhibin concentrations before and during gonadotropin treatment in men with hypogonadotropic hypogonadism: physiological and clinical implications. McLachlan, R.I., Finkel, D.M., Bremner, W.J., Snyder, P.J. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
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