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Gene Review

MCM8  -  minichromosome maintenance complex...

Homo sapiens

Synonyms: C20orf154, DNA helicase MCM8, MGC119522, MGC119523, MGC12866, ...
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Disease relevance of MCM8

  • In a case of choriocarcinoma MCM8 mRNA is aberrant, leading to expression of a protein lacking 16 amino acids [1].
  • In several cases of colon adenocarcinoma MCM8 expression is greatly reduced relative to matched non-cancerous tissue [1].

High impact information on MCM8


Biological context of MCM8

  • The MCM8 gene, consisting of 19 exons, is located contrapodal to a gene, consisting of 11 exons, encoding a homolog of the yeast GCD10 gene product [1].
  • A new member of the MCM protein family encoded by the human MCM8 gene, located contrapodal to GCD10 at chromosome band 20p12.3-13 [1].
  • Like MCM8, MCM9 is only present in the genome of higher eukaryotes [4].


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