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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Choriocarcinoma

  • The expression of VEGF mRNA and protein is drastically up-regulated by hypoxia in choriocarcinoma cells, whereas expression of PIGF is not affected by the low concentration of oxygen [1].
  • Thus under identical culture conditions, a bronchogenic carcinoma clonal line secreted only alpha-subunit, whereas a choriocarcinoma line secreted only HCG; these findings implied major differences in cellular control mechanisms [2].
  • Concentrations up to 50 000 microgram/l were found in the sera of patients with hydatidiform mole, invasive mole, choriocarcinoma, and malignant teratoma. beta1-glycoprotein concentrations were generally much lower than corresponding concentrations of chorionic gonadotrophin which is the most reliable marker for trophoblastic tumours [3].
  • To examine the role of trophoblast differentiation in the expression of the hCG and hPL genes, we studied the cytological distribution of their messenger RNA (mRNA) in tissue sections of human hydatidiform mole and choriocarcinoma by in situ hybridization [4].
  • RNA transcripts of the HERV-R (ERV3) human provirus that are abundant in placenta but absent in choriocarcinoma contain nonproviral genomic sequences at their 3' ends [5].

High impact information on Choriocarcinoma


Chemical compound and disease context of Choriocarcinoma


Biological context of Choriocarcinoma


Anatomical context of Choriocarcinoma


Gene context of Choriocarcinoma


Analytical, diagnostic and therapeutic context of Choriocarcinoma


  1. In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor. Cao, Y., Linden, P., Shima, D., Browne, F., Folkman, J. J. Clin. Invest. (1996) [Pubmed]
  2. Ectopic and eutopic secretion of chorionic gonadotropin and its sub-nits in vitro: comparison of clonal strains from carcinomas of lung and placenta. Lieblich, J.M., Weintraub, B.D., Krauth, G.H., Kohler, P.O., Rabson, A.S., Rosen, S.W. J. Natl. Cancer Inst. (1976) [Pubmed]
  3. Serum-SP1-pregnancy-specific-beta-glycoprotein in choriocarcinoma and other neoplastic disease. Searle, F., Leake, B.A., Bagshawe, K.D., Dent, J. Lancet (1978) [Pubmed]
  4. Cytological distribution of chorionic gonadotropin subunit and placental lactogen messenger RNA in neoplasms derived from human placenta. Hoshina, M., Hussa, R., Pattillo, R., Boime, I. J. Cell Biol. (1983) [Pubmed]
  5. Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Krüppel. Kato, N., Shimotohno, K., VanLeeuwen, D., Cohen, M. Mol. Cell. Biol. (1990) [Pubmed]
  6. Expression of HLA-A, -B, and -C and beta 2-microglobulin antigens in human choriocarcinoma cell lines. Trowsdale, J., Travers, P., Bodmer, W.F., Patillo, R.A. J. Exp. Med. (1980) [Pubmed]
  7. Expression of the human c-fms proto-oncogene product (colony-stimulating factor-1 receptor) on peripheral blood mononuclear cells and choriocarcinoma cell lines. Rettenmier, C.W., Sacca, R., Furman, W.L., Roussel, M.F., Holt, J.T., Nienhuis, A.W., Stanley, E.R., Sherr, C.J. J. Clin. Invest. (1986) [Pubmed]
  8. Characterization of a carboxyterminal peptide fragment of the human choriogonadotropin beta-subunit excreted in the urine of a woman with choriocarcinoma. Amr, S., Wehmann, R.E., Birken, S., Canfield, R.E., Nisula, B.C. J. Clin. Invest. (1983) [Pubmed]
  9. Increased "pregnancy-specific" beta1-glycoprotein in certain nonseminomatous germ cell tumors. Rosen, S.W., Javadpour, N., Calvert, I., Kaminska, J. J. Natl. Cancer Inst. (1979) [Pubmed]
  10. The alpha 1/beta 1 and alpha 6/beta 1 integrin heterodimers mediate cell attachment to distinct sites on laminin. Hall, D.E., Reichardt, L.F., Crowley, E., Holley, B., Moezzi, H., Sonnenberg, A., Damsky, C.H. J. Cell Biol. (1990) [Pubmed]
  11. Phosphorylation of the secreted, free alpha subunit of human chorionic gonadotropin. Saccuzzo, J.E., Krzesicki, R.F., Perini, F., Ruddon, R.W. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  12. Regulation of thyroid hormone receptor-mediated transcription by a cytosol protein. Ashizawa, K., Cheng, S.Y. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  13. The stimulation by methotrexate of human chorionic gonadotropin and placental alkaline phosphatase in cultured choriocarcinoma cells. Speeg, K.V., Azizkhan, J.C., Stromberg, K. Cancer Res. (1976) [Pubmed]
  14. Effects of adenosine cyclic nucleotides on the synthesis of human chorionic gonadotropin in transformed human placental cells. Chou, J.Y. Cancer Res. (1980) [Pubmed]
  15. Detection of membrane-bound HLA-G translated products with a specific monoclonal antibody. Bensussan, A., Mansur, I.G., Mallet, V., Rodriguez, A.M., Girr, M., Weiss, E.H., Brem, G., Boumsell, L., Gluckman, E., Dausset, J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  16. Characterization of the human c-fms gene product and its expression in cells of the monocyte-macrophage lineage. Woolford, J., Rothwell, V., Rohrschneider, L. Mol. Cell. Biol. (1985) [Pubmed]
  17. Structural differences found in the asparagine-linked sugar chains of human chorionic gonadotropins purified from the urine of patients with invasive mole and with choriocarcinoma. Endo, T., Nishimura, R., Kawano, T., Mochizuki, M., Kobata, A. Cancer Res. (1987) [Pubmed]
  18. DNA binding of TEA/ATTS domain factors is regulated by protein kinase C phosphorylation in human choriocarcinoma cells. Jiang, S.W., Dong, M., Trujillo, M.A., Miller, L.J., Eberhardt, N.L. J. Biol. Chem. (2001) [Pubmed]
  19. Glucose regulates insulin mitogenic effect by modulating SHP-2 activation and localization in JAr cells. Bifulco, G., Di Carlo, C., Caruso, M., Oriente, F., Di Spiezio Sardo, A., Formisano, P., Beguinot, F., Nappi, C. J. Biol. Chem. (2002) [Pubmed]
  20. Lack of effective messenger RNA for beta 2-microglobulin in a gestational human choriocarcinoma cell line (GCH-1). Tanaka, K., Nabeshima, Y., Takahashi, H., Takeuchi, S., Nabeshima, Y., Ogata, K. Cancer Res. (1981) [Pubmed]
  21. Peptide mapping of the human transferrin receptor in normal and transformed cells. Stein, B.S., Sussman, H.H. J. Biol. Chem. (1983) [Pubmed]
  22. Demonstration of equilibrative nucleoside transporters (hENT1 and hENT2) in nuclear envelopes of cultured human choriocarcinoma (BeWo) cells by functional reconstitution in proteoliposomes. Mani, R.S., Hammond, J.R., Marjan, J.M., Graham, K.A., Young, J.D., Baldwin, S.A., Cass, C.E. J. Biol. Chem. (1998) [Pubmed]
  23. Recognition of nonclassical HLA class I antigens by gamma delta T cells during pregnancy. Barakonyi, A., Kovacs, K.T., Miko, E., Szereday, L., Varga, P., Szekeres-Bartho, J. J. Immunol. (2002) [Pubmed]
  24. Disulfide bond formation is not required for human chorionic gonadotropin subunit association. Studies with dithiothreitol in JEG-3 cells. Singh, V., Merz, W.E. J. Biol. Chem. (2000) [Pubmed]
  25. Expression of plasma glutathione peroxidase in human liver in addition to kidney, heart, lung, and breast in humans and rodents. Chu, F.F., Esworthy, R.S., Doroshow, J.H., Doan, K., Liu, X.F. Blood (1992) [Pubmed]
  26. Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein. Landers, J.E., Cassel, S.L., George, D.L. Cancer Res. (1997) [Pubmed]
  27. Evidence for the expression of HLAA-C class I mRNA and protein by human first trimester trophoblast. King, A., Boocock, C., Sharkey, A.M., Gardner, L., Beretta, A., Siccardi, A.G., Loke, Y.W. J. Immunol. (1996) [Pubmed]
  28. A 5'-distal enhanceosome in the PDGF-A gene is activated in choriocarcinoma cells via ligand-independent binding of vitamin D receptor and constitutive jun kinase signaling. Pedigo, N.G., Zhang, H., Bruno, M.E., Kaetzel, C.S., Dugan, A.R., Shanehsaz, P., Hennigan, R.F., Xing, Z., Koszewski, N.J., Kaetzel, D.M. Oncogene (2005) [Pubmed]
  29. Epidermal growth factor receptor expression and activation in nonseminomatous germ cell tumors. Moroni, M., Veronese, S., Schiavo, R., Carminati, O., Sorensen, B.S., Gambacorta, M., Siena, S. Clin. Cancer Res. (2001) [Pubmed]
  30. Molecular properties of F9 embryoglycan recognized by a unique antibody in sera from patients with germ cell tumors. Kawata, M., Sekiya, S., Takamizawa, H., Muramatsu, T., Okumura, K. Cancer Res. (1987) [Pubmed]
  31. Transduction of human trophoblastic cells by replication-deficient recombinant viral vectors. Promoting cellular differentiation affects virus entry. Parry, S., Holder, J., Halterman, M.W., Weitzman, M.D., Davis, A.R., Federoff, H., Strauss, J.F. Am. J. Pathol. (1998) [Pubmed]
  32. Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II. Götting, C., Kuhn, J., Zahn, R., Brinkmann, T., Kleesiek, K. J. Mol. Biol. (2000) [Pubmed]
  33. Monoclonal antibody to human T-cell leukemia virus p19 defines polypeptide antigen in human choriocarcinoma cells and syncytiotrophoblasts of first-trimester placentas. Suni, J., Närvänen, A., Wahlström, T., Lehtovirta, P., Vaheri, A. Int. J. Cancer (1984) [Pubmed]
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