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Gene Review

Pick1  -  protein interacting with PRKCA 1

Rattus norvegicus

Synonyms: PRKCA-binding protein, Prkcabp, Protein interacting with C kinase 1, Protein kinase C-alpha-binding protein
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High impact information on Pick1

  • Co-immunoprecipitation using anti-Pick1 antibodies revealed that the overexpressed GluR2 C-terminal decoy indeed prevented Pick1 from interacting with the endogenous GluR2/3 [1].
  • In parallel, the NMDA treatment markedly altered the interaction between the AMPA receptor subunits and their associating molecule(s); the association of PDZ molecules, including Pick1, with GluR2/3 was enhanced in a protein-kinase-C-dependent manner [1].
  • Some comments on the Pick and Mizel microassay method for measurement of hydrogen peroxide production by macrophages [2].
  • The freeze-thawing method of Pick (1981) gave the best results; large unilamellar liposomes that mimic the membrane of endoplasmic reticulum were obtained [3].

Biological context of Pick1

  • Therefore, these observations suggest that the NMDA-induced down-regulation of the functional AMPA receptors involves the interaction between GluR2/3 subunits and Pick1 [1].

Associations of Pick1 with chemical compounds


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