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Gene Review

Pick1  -  protein interacting with C kinase 1

Mus musculus

Synonyms: PRKCA-binding protein, Prkcabp, Protein interacting with C kinase 1, Protein kinase C-alpha-binding protein
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Disease relevance of Pick1


Psychiatry related information on Pick1


High impact information on Pick1

  • NFT and Pick-body-like neuronal lesions occurred in the amygdala, septal nuclei, pre-optic nuclei, hypothalamus, midbrain, pons, medulla, deep cerebellar nuclei and spinal cord, with tau-immunoreactive pre-tangles in the cortex, hippocampus and basal ganglia [1].
  • Localization of Niemann-Pick C1 protein in astrocytes: implications for neuronal degeneration in Niemann- Pick type C disease [7].
  • Niemann-Pick type C disease and intracellular cholesterol trafficking [8].
  • Previous reports indicated that resident macrophages produced low or nondetectable quantities of H2O2 (1-10 nmol H2O2/mg resident macrophage protein) when measured by the phenol red assay described by Pick and Mizel [5] [9].
  • Mutant mice with Niemann-Pick type C disease were treated with the peroxisomal inducer perfluorooctanoic acid, which increased peroxisomal beta-oxidation and catalase activity to the same level as in control mice [10].

Biological context of Pick1

  • It appears that in Niemann-Pick type C disease treatment with appropriate peroxisomal inducers restores basic cellular functions, indicating a relationship between peroxisomes and cholesterol homeostasis, and thereby may effectively interfere with the development of the disease [10].
  • A modifier of Niemann Pick C 1 maps to mouse chromosome 19 [11].

Anatomical context of Pick1

  • Flow cytometry was performed to evaluate the effect on peritoneal macrophage survival and phagocytic function and the Pick test was used to determine peroxide production in order to estimate toxicity and potential impairment of macrophage function caused by the chemicals [12].


  1. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Lewis, J., McGowan, E., Rockwood, J., Melrose, H., Nacharaju, P., Van Slegtenhorst, M., Gwinn-Hardy, K., Paul Murphy, M., Baker, M., Yu, X., Duff, K., Hardy, J., Corral, A., Lin, W.L., Yen, S.H., Dickson, D.W., Davies, P., Hutton, M. Nat. Genet. (2000) [Pubmed]
  2. Cholesterol metabolism in the brain. Dietschy, J.M., Turley, S.D. Curr. Opin. Lipidol. (2001) [Pubmed]
  3. Lipocalin-type prostaglandin D synthase is up-regulated in oligodendrocytes in lysosomal storage diseases and binds gangliosides. Mohri, I., Taniike, M., Okazaki, I., Kagitani-Shimono, K., Aritake, K., Kanekiyo, T., Yagi, T., Takikita, S., Kim, H.S., Urade, Y., Suzuki, K. J. Neurochem. (2006) [Pubmed]
  4. Degeneration of neurons and glia in the Niemann-Pick C mouse is unrelated to the low-density lipoprotein receptor. German, D.C., Quintero, E.M., Liang, C., Xie, C., Dietschy, J.M. Neuroscience (2001) [Pubmed]
  5. Patterned cerebellar Purkinje cell death in a transgenic mouse model of Niemann Pick type A/B disease. Sarna, J., Miranda, S.R., Schuchman, E.H., Hawkes, R. Eur. J. Neurosci. (2001) [Pubmed]
  6. Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics. Iwatsubo, T., Hasegawa, M., Ihara, Y. Acta Neuropathol. (1994) [Pubmed]
  7. Localization of Niemann-Pick C1 protein in astrocytes: implications for neuronal degeneration in Niemann- Pick type C disease. Patel, S.C., Suresh, S., Kumar, U., Hu, C.Y., Cooney, A., Blanchette-Mackie, E.J., Neufeld, E.B., Patel, R.C., Brady, R.O., Patel, Y.C., Pentchev, P.G., Ong, W.Y. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  8. Niemann-Pick type C disease and intracellular cholesterol trafficking. Chang, T.Y., Reid, P.C., Sugii, S., Ohgami, N., Cruz, J.C., Chang, C.C. J. Biol. Chem. (2005) [Pubmed]
  9. Optimization of peroxide production by resident macrophages. Cook-Mills, J.M., Fraker, P.J. J. Leukoc. Biol. (1993) [Pubmed]
  10. Reduced cholesterol accumulation and improved deficient peroxisomal functions in a murine model of Niemann-Pick type C disease upon treatment with peroxisomal proliferators. Schedin, S., Pentchev, P., Dallner, G. Biochem. Pharmacol. (1998) [Pubmed]
  11. A modifier of Niemann Pick C 1 maps to mouse chromosome 19. Zhang, J., Erickson, R.P. Mamm. Genome (2000) [Pubmed]
  12. Prevention of postoperative peritoneal adhesions: effects of lysozyme, polylysine and polyglutamate versus hyaluronic acid. Nehéz, L., Vödrös, D., Axelsson, J., Tingstedt, B., Lindman, B., Andersson, R. Scand. J. Gastroenterol. (2005) [Pubmed]
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