The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PICK1  -  protein interacting with PRKCA 1

Homo sapiens

Synonyms: MGC15204, PICK, PRKCA-binding protein, PRKCABP, Protein interacting with C kinase 1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PICK1


Psychiatry related information on PICK1


High impact information on PICK1

  • In addition, I hypothesize that ATPases associated with various cellular activities regulate the recycling of soluble lipid carriers and that the Niemann Pick C1 protein facilitates the delivery of sterols from endosomal membranes to ORPs and/or the ensuing membrane dissociation of ORPs [10].
  • LTD can be rescued in cerebellar cultures from mice lacking PICK1 by transfection of wild-type PICK1 but not by a PDZ mutant or a BAR domain mutant deficient in lipid binding, indicating the importance of these domains in PICK1 function [11].
  • Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP [12].
  • In dopaminergic neurons, PICK1 colocalizes with the dopamine transporter (DAT) and forms a stable protein complex [13].
  • PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7 [14].

Chemical compound and disease context of PICK1


Biological context of PICK1

  • These results indicate that the scaffolding protein, PICK1, plays an essential role in the control of synaptic transmission by the mGlu7a receptor complex [14].
  • We identified the PDZ domain protein PICK1 as an interactor of BNaC1(ASIC2) in a yeast two-hybrid screen [1].
  • The PICK1 gene may play a role in conferring susceptibility to schizophrenia as it has been mapped to chromosome 22q13.1, a region thought to contain a gene for schizophrenia [20].
  • Results demonstrated that the PICK1 rs3952 genotype and allele distribution was significantly different between the two groups [20].
  • Interestingly, PKC activation in neurons increases the Ser880 phosphorylation of GluR2 subunits and recruits PICK1 to excitatory synapses [21].

Anatomical context of PICK1

  • Both PICK1 and BNaC1alpha are also coexpressed by some pyramidal neurons of the cortex, by pyramidal neurons of the CA3 region of hippocampus, and by cerebellar Purkinje neurons, localizing to their dendrites and cell bodies [1].
  • These findings indicate a previously unidentified role for PICK1 in anchoring PKCalpha to mitochondria in a ligand-specific manner [22].
  • 12-O-Tetradecanoylphorbol-13-acetate stimulation, in contrast, causes translocation of PKCalpha to the plasma membrane, whereas the majority of PICK1 remains in a cytoplasmic punctate pattern [22].
  • PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells [22].
  • Double staining with organelle markers and anti-rPICK1 antibodies reveals that PICK1 is associated with mitochondria but not with endoplasmic reticulum or Golgi in NIH 3T3 cells [22].

Associations of PICK1 with chemical compounds

  • We show by two-hybrid assays, glutathione S-transferase pull-down assays, and coimmunoprecipitations that the BNaC1-PICK1 interaction is specific, and that coexpression of both proteins leads to their clustering in intracellular compartments [1].
  • The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs [23].
  • Our results showed that the PICK1 PDZ domain binds the type II sequence presented by the human dopamine transporter (-WLKV) with an almost 15-fold and >100-fold higher affinity than the type I sequences presented by protein kinase Calpha (-QSAV) and the beta(2)-adrenergic receptor (-DSLL), respectively [24].
  • Our findings implicating PICK1 as a susceptibility gene for SZ are consistent with a role for D-serine in the disease [25].
  • NMDA receptors mediate calcium-dependent, bidirectional changes in dendritic PICK1 clustering [26].

Physical interactions of PICK1

  • Our results suggest a potential competition between TIS21 and PKC for binding to PICK1 [27].
  • Recent findings, together with previously established evidence, highlight the PDZ-domain-containing protein interacting with C-kinase 1 (PICK1) as a promising candidate for a schizophrenia susceptibility gene [28].
  • Serine racemase binds to PICK1: potential relevance to schizophrenia [25].
  • One model of AMPAR endocytosis entails the cotargeting of the GluR2-interacting protein PICK1 and activated PKC to synapses [26].

Co-localisations of PICK1

  • Immunostaining of cultured hippocampal neurons demonstrates that the Ser880-phosphorylated GluR2 subunits are enriched and colocalized with PICK1 in the dendrites, with very little staining observed at excitatory synapses [21].

Other interactions of PICK1

  • Furthermore, we provide evidence for three new CAR interacting partners, including MAGI-1b, PICK1 and PSD-95 [29].
  • We propose dual roles of the hDAT C terminus: a role independent of PDZ interactions for ER export and surface targeting, and a not fully clarified role involving PDZ interactions with proteins such as PICK1 [30].
  • Amongst the first interaction partners to be discovered were NSF, ABP, GRIP and PICK1, which bind the AMPA receptor subunit GLUA2 [31].
  • In this study, we identify and characterize protein interacting with C-kinase (PICK1) as a protein interactor of the D-serine synthesizing enzyme, serine racemase (SR) [25].
  • Bidirectional NMDAR-mediated changes in PICK1 localization are determined by the magnitude of receptor-activated dendritic calcium signals [26].

Analytical, diagnostic and therapeutic context of PICK1


  1. The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons. Duggan, A., Garcia-Anoveros, J., Corey, D.P. J. Biol. Chem. (2002) [Pubmed]
  2. Herpes-simplex viral genome and senile and presenile dementias of Alzheimer and Pick. Middleton, P.J., Petric, M., Kozak, M., Rewcastle, N.B., McLachlan, D.R. Lancet (1980) [Pubmed]
  3. Cognitive, neuroimaging, and pathological studies in a patient with Pick's disease. Lieberman, A.P., Trojanowski, J.Q., Lee, V.M., Balin, B.J., Ding, X.S., Greenberg, J., Morrison, D., Reivich, M., Grossman, M. Ann. Neurol. (1998) [Pubmed]
  4. Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disorders. Joachim, C.L., Morris, J.H., Kosik, K.S., Selkoe, D.J. Ann. Neurol. (1987) [Pubmed]
  5. Sporadic Pick's disease: a tauopathy characterized by a spectrum of pathological tau isoforms in gray and white matter. Zhukareva, V., Mann, D., Pickering-Brown, S., Uryu, K., Shuck, T., Shah, K., Grossman, M., Miller, B.L., Hulette, C.M., Feinstein, S.C., Trojanowski, J.Q., Lee, V.M. Ann. Neurol. (2002) [Pubmed]
  6. Dementia and motor neuron disease: morphometric, biochemical, and Golgi studies. Horoupian, D.S., Thal, L., Katzman, R., Terry, R.D., Davies, P., Hirano, A., DeTeresa, R., Fuld, P.A., Petito, C., Blass, J. Ann. Neurol. (1984) [Pubmed]
  7. Clinicopathological correlates in frontotemporal dementia. Hodges, J.R., Davies, R.R., Xuereb, J.H., Casey, B., Broe, M., Bak, T.H., Kril, J.J., Halliday, G.M. Ann. Neurol. (2004) [Pubmed]
  8. The pathology and nosology of primary progressive aphasia. Kertesz, A., Hudson, L., Mackenzie, I.R., Munoz, D.G. Neurology (1994) [Pubmed]
  9. Kluver-Bucy syndrome in Pick disease: clinical and pathologic correlations. Cummings, J.L., Duchen, L.W. Neurology (1981) [Pubmed]
  10. Nonvesicular sterol transport: two protein families and a sterol sensor? Yang, H. Trends Cell Biol. (2006) [Pubmed]
  11. Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression. Steinberg, J.P., Takamiya, K., Shen, Y., Xia, J., Rubio, M.E., Yu, S., Jin, W., Thomas, G.M., Linden, D.J., Huganir, R.L. Neuron (2006) [Pubmed]
  12. Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP. Hirbec, H., Francis, J.C., Lauri, S.E., Braithwaite, S.P., Coussen, F., Mulle, C., Dev, K.K., Coutinho, V., Meyer, G., Isaac, J.T., Collingridge, G.L., Henley, J.M., Couthino, V. Neuron (2003) [Pubmed]
  13. Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. Torres, G.E., Yao, W.D., Mohn, A.R., Quan, H., Kim, K.M., Levey, A.I., Staudinger, J., Caron, M.G. Neuron (2001) [Pubmed]
  14. PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7. Perroy, J., El Far, O., Bertaso, F., Pin, J.P., Betz, H., Bockaert, J., Fagni, L. EMBO J. (2002) [Pubmed]
  15. Severity of gliosis in Pick's disease and frontotemporal lobar degeneration: tau-positive glia differentiate these disorders. Schofield, E., Kersaitis, C., Shepherd, C.E., Kril, J.J., Halliday, G.M. Brain (2003) [Pubmed]
  16. 4-hydroxy-2-nonenal pyrrole adducts in human neurodegenerative disease. Montine, K.S., Kim, P.J., Olson, S.J., Markesbery, W.R., Montine, T.J. J. Neuropathol. Exp. Neurol. (1997) [Pubmed]
  17. Alterations of muscarinic acetylcholine receptors in atypical Pick's disease without Pick bodies. Odawara, T., Shiozaki, K., Iseki, E., Hino, H., Kosaka, K. J. Neurol. Neurosurg. Psychiatr. (2003) [Pubmed]
  18. Pick's disease: hyperphosphorylated tau protein segregates to the somatoaxonal compartment. Probst, A., Tolnay, M., Langui, D., Goedert, M., Spillantini, M.G. Acta Neuropathol. (1996) [Pubmed]
  19. Magnetic resonance spectroscopic study of Alzheimer's disease and frontotemporal dementia/Pick complex. Mihara, M., Hattori, N., Abe, K., Sakoda, S., Sawada, T. Neuroreport (2006) [Pubmed]
  20. Association study of PICK1 rs3952 polymorphism and schizophrenia. Hong, C.J., Liao, D.L., Shih, H.L., Tsai, S.J. Neuroreport (2004) [Pubmed]
  21. Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins. Chung, H.J., Xia, J., Scannevin, R.H., Zhang, X., Huganir, R.L. J. Neurosci. (2000) [Pubmed]
  22. PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells. Wang, W.L., Yeh, S.F., Chang, Y.I., Hsiao, S.F., Lian, W.N., Lin, C.H., Huang, C.Y., Lin, W.J. J. Biol. Chem. (2003) [Pubmed]
  23. The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. Hirbec, H., Perestenko, O., Nishimune, A., Meyer, G., Nakanishi, S., Henley, J.M., Dev, K.K. J. Biol. Chem. (2002) [Pubmed]
  24. Molecular determinants for the complex binding specificity of the PDZ domain in PICK1. Madsen, K.L., Beuming, T., Niv, M.Y., Chang, C.W., Dev, K.K., Weinstein, H., Gether, U. J. Biol. Chem. (2005) [Pubmed]
  25. Serine racemase binds to PICK1: potential relevance to schizophrenia. Fujii, K., Maeda, K., Hikida, T., Mustafa, A.K., Balkissoon, R., Xia, J., Yamada, T., Ozeki, Y., Kawahara, R., Okawa, M., Huganir, R.L., Ujike, H., Snyder, S.H., Sawa, A. Mol. Psychiatry (2006) [Pubmed]
  26. NMDA receptors mediate calcium-dependent, bidirectional changes in dendritic PICK1 clustering. Sossa, K.G., Court, B.L., Carroll, R.C. Mol. Cell. Neurosci. (2006) [Pubmed]
  27. Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1. Lin, W.J., Chang, Y.F., Wang, W.L., Huang, C.Y. Biochem. J. (2001) [Pubmed]
  28. The schizophrenic faces of PICK1. Dev, K.K., Henley, J.M. Trends Pharmacol. Sci. (2006) [Pubmed]
  29. A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth. Excoffon, K.J., Hruska-Hageman, A., Klotz, M., Traver, G.L., Zabner, J. J. Cell. Sci. (2004) [Pubmed]
  30. Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions. Bjerggaard, C., Fog, J.U., Hastrup, H., Madsen, K., Loland, C.J., Javitch, J.A., Gether, U. J. Neurosci. (2004) [Pubmed]
  31. Functional roles of protein interactions with AMPA and kainate receptors. Collingridge, G.L., Isaac, J.T. Neurosci. Res. (2003) [Pubmed]
  32. Protein kinase C stimulates the acid-sensing ion channel ASIC2a via the PDZ domain-containing protein PICK1. Baron, A., Deval, E., Salinas, M., Lingueglia, E., Voilley, N., Lazdunski, M. J. Biol. Chem. (2002) [Pubmed]
  33. Lamina-specific abnormalities of AMPA receptor trafficking and signaling molecule transcripts in the prefrontal cortex in schizophrenia. Beneyto, M., Meador-Woodruff, J.H. Synapse (2006) [Pubmed]
  34. Frontotemporal dementia with Pick-type histology associated with Q336R mutation in the tau gene. Pickering-Brown, S.M., Baker, M., Nonaka, T., Ikeda, K., Sharma, S., Mackenzie, J., Simpson, S.A., Moore, J.W., Snowden, J.S., de Silva, R., Revesz, T., Hasegawa, M., Hutton, M., Mann, D.M. Brain (2004) [Pubmed]
  35. Abnormal group I metabotropic glutamate receptor expression and signaling in the frontal cortex in Pick disease. Dalfó, E., Albasanz, J.L., Rodríguez, A., Martín, M., Ferrer, I. J. Neuropathol. Exp. Neurol. (2005) [Pubmed]
  36. Autopsy-proven, sporadic pick disease with onset at age 25 years. Coleman, L.W., Digre, K.B., Stephenson, G.M., Townsend, J.J. Arch. Neurol. (2002) [Pubmed]
WikiGenes - Universities