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Gene Review

NTNG2  -  netrin G2

Homo sapiens

Synonyms: KIAA1857, LHLL9381, LMNT2, Laminet-2, Lmnt2, ...
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Psychiatry related information on NTNG2


High impact information on NTNG2

  • BACKGROUND: The netrin-G1 (NTNG1) and -G2 (NTNG2) genes, recently cloned from mouse, play a role in the formation and/or maintenance of glutamatergic neural circuitry [2].
  • An association between NTNG2 and schizophrenia was also observed with SNPs and haplotypes that clustered in the 5' region of the gene [2].
  • KIAA1857-netrin-G2 belongs to the netrins and might then be a tumor suppressor gene in bladder cancer, as netrin1 receptor DCC has been implicated in tumorigenesis [3].
  • We here identified in mice a novel member netrin-G2 which constitute a subfamily with netrin-G1 among the UNC6/netrin family [4].
  • We sequenced the nine coding exons of NTNG1 and identified four sequence variants, none of which were likely to be pathogenic [1].

Analytical, diagnostic and therapeutic context of NTNG2

  • Reverse transcriptase PCR detected nine alternatively spliced isoforms including four novel variants of NTNG1 from adult brain [5].


  1. NTNG1 mutations are a rare cause of Rett syndrome. Archer, H.L., Evans, J.C., Millar, D.S., Thompson, P.W., Kerr, A.M., Leonard, H., Christodoulou, J., Ravine, D., Lazarou, L., Grove, L., Verity, C., Whatley, S.D., Pilz, D.T., Sampson, J.R., Clarke, A.J. Am. J. Med. Genet. A (2006) [Pubmed]
  2. A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia. Aoki-Suzuki, M., Yamada, K., Meerabux, J., Iwayama-Shigeno, Y., Ohba, H., Iwamoto, K., Takao, H., Toyota, T., Suto, Y., Nakatani, N., Dean, B., Nishimura, S., Seki, K., Kato, T., Itohara, S., Nishikawa, T., Yoshikawa, T. Biol. Psychiatry (2005) [Pubmed]
  3. Expression in bladder transitional cell carcinoma by real-time quantitative reverse transcription polymerase chain reaction array of 65 genes at the tumor suppressor locus 9q34.1-2: identification of 5 candidates tumor suppressor genes. Amira, N., Cancel-Tassin, G., Bernardini, S., Cochand-Priollet, B., Bittard, H., Mangin, P., Fournier, G., Latil, A., Cussenot, O. Int. J. Cancer (2004) [Pubmed]
  4. Complementary expression and neurite outgrowth activity of netrin-G subfamily members. Nakashiba, T., Nishimura, S., Ikeda, T., Itohara, S. Mech. Dev. (2002) [Pubmed]
  5. Human netrin-G1 isoforms show evidence of differential expression. Meerabux, J.M., Ohba, H., Fukasawa, M., Suto, Y., Aoki-Suzuki, M., Nakashiba, T., Nishimura, S., Itohara, S., Yoshikawa, T. Genomics (2005) [Pubmed]
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