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Gene Review

SRB8  -  Srb8p

Saccharomyces cerevisiae S288c

Synonyms: GIG1, MED12, Mediator complex subunit 12, Mediator of RNA polymerase II transcription subunit 12, NUT6, ...
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High impact information on SRB8

  • Our findings provide experimental evidence for recent suggestions that TRAP230/ARC240 and TRAP240/ARC250 may indeed be the Srb8 and Srb9 homologues of mammalian Mediator [1].
  • Srb9 is part of the Srb8-Srb11 complex, associated with the Mediator coactivator [2].
  • Gis4 was originally isolated as a multi-copy suppressor of a Gal--phenotype in the triple mutant snf1 mig1 srb8 [3].
  • These down-regulated genes are involved in messenger RNA splicing and ribosomal protein biogenesis and in transcriptional regulator (SRB8, MIG1) [4].


  1. TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution. Samuelsen, C.O., Baraznenok, V., Khorosjutina, O., Spahr, H., Kieselbach, T., Holmberg, S., Gustafsson, C.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. The Saccharomyces cerevisiae Srb8-Srb11 complex functions with the SAGA complex during Gal4-activated transcription. Larschan, E., Winston, F. Mol. Cell. Biol. (2005) [Pubmed]
  3. SCFGrr1-mediated ubiquitination of Gis4 modulates glucose response in yeast. La Rue, J., Tokarz, S., Lanker, S. J. Mol. Biol. (2005) [Pubmed]
  4. Functional genomic analysis of commercial baker's yeast during initial stages of model dough-fermentation. Tanaka, F., Ando, A., Nakamura, T., Takagi, H., Shima, J. Food Microbiol. (2006) [Pubmed]
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