Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

ALR2 - putative Mg(2+) transporter ALR2

Saccharomyces cerevisiae S288c

Synonyms: Aluminum resistance protein 2, Magnesium transporter ALR2, YFL050C

Mayr, P. et al., MacDiarmid, C.W. et al., Hajji, K. et al., Wachek, M. et al., Kern, A.L. et al., et al.

Mayr, Brüggler, Kulbe, Nidetzky,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on ALR2

Yeast strains lacking ALR gene activity required additional Mg2+ for growth, and expression of either ALR1 or ALR2 corrected the Mg(2+)-requiring phenotype [1].
Alr2p contributes poorly to Mg(2+) uptake [2].

Biological context of ALR2

Disruption of YOL130w (also known as ALR1) produced a lethal phenotype, despite the presence of a highly similar gene in the yeast genome (ALR2/YFL050C) [3].

Anatomical context of ALR2

Oligomerization of the Mg(2+)-transport proteins Alr1p and Alr2p in yeast plasma membrane [2].

Associations of ALR2 with chemical compounds

Two genes in Saccharomyces cerevisiae, ALR1 and ALR2, encode proteins putatively involved in Mg(2+) uptake [4].
ALR1 is strictly specific for NADPH (2.4 x 10(5) M(-1) s(-1)) whereas ALR2 utilises NADH and NADPH with similar specificity constants of approximately 2-4 x 10(5) M(-1) s(-1) [5].

Other interactions of ALR2

Two genes in Saccharomyces cerevisiae, ALR1 and ALR2, encode transmembrane proteins involved in Mg2+ uptake [6].

References

Overexpression of the Saccharomyces cerevisiae magnesium transport system confers resistance to aluminum ion. MacDiarmid, C.W., Gardner, R.C. J. Biol. Chem. (1998) [Pubmed]
Oligomerization of the Mg(2+)-transport proteins Alr1p and Alr2p in yeast plasma membrane. Wachek, M., Aichinger, M.C., Stadler, J.A., Schweyen, R.J., Graschopf, A. FEBS J. (2006) [Pubmed]
Disruption and phenotypic analysis of seven ORFs from the left arm of chromosome XV of Saccharomyces cerevisiae. Hajji, K., Clotet, J., Ariño, J. Yeast (1999) [Pubmed]
Large Mg(2+)-dependent currents are associated with the increased expression of ALR1 in Saccharomyces cerevisiae. Liu, G.J., Martin, D.K., Gardner, R.C., Ryan, P.R. FEMS Microbiol. Lett. (2002) [Pubmed]
D-Xylose metabolism by Candida intermedia: isolation and characterisation of two forms of aldose reductase with different coenzyme specificities. Mayr, P., Brüggler, K., Kulbe, K.D., Nidetzky, B. J. Chromatogr. B Biomed. Sci. Appl. (2000) [Pubmed]
The function of Alr1p of Saccharomyces cerevisiae in cadmium detoxification: insights from phylogenetic studies and particle-induced X-ray emission. Kern, A.L., Bonatto, D., Dias, J.F., Yoneama, M.L., Brendel, M., Pêgas Henriques, J.A. Biometals (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AGOS_ADL171W	Ashbya gossypii ATCC 10895
KLLA0E07261g	Kluyveromyces lactis NRRL Y-1140
ALR1	Saccharomyces cerevisiae S288c

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.