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Gene Review

SEC10  -  Sec10p

Saccharomyces cerevisiae S288c

Synonyms: Exocyst complex component SEC10, L9362.12, YLR166C
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High impact information on SEC10

  • When single exocytotic events were imaged by total internal reflection fluorescence microscopy, the fluorescence of the insulin surrogate, neuropeptide Y-monomeric red fluorescent protein brightened, diffused, and then vanished with kinetics that were unaffected by overexpression of truncated SEC8 or SEC10 [1].
  • By co-immunoprecipitation we show that Sec10, which forms an exocyst subcomplex with Sec15, specifically associates with the Sec61beta component of the translocon and that Sec10 overexpression increases the association of other exocyst complex members with Sec61beta [2].
  • Overexpression of human Sec10 resulted in more efficient and rapid cyst formation and increased tubule formation upon stimulation with hepatocyte growth factor [3].
  • When the exocyst subunit human Sec10 was exogenously expressed in epithelial Madin-Darby canine kidney cells, there was a selective increase in the synthesis and delivery of apical and basolateral secretory proteins and a basolateral plasma membrane protein, but not an apical plasma membrane protein [3].
  • Dominant negative alleles of SEC10 reveal distinct domains involved in secretion and morphogenesis in yeast [4].

Biological context of SEC10


  1. Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis. Tsuboi, T., Ravier, M.A., Xie, H., Ewart, M.A., Gould, G.W., Baldwin, S.A., Rutter, G.A. J. Biol. Chem. (2005) [Pubmed]
  2. The exocyst affects protein synthesis by acting on the translocation machinery of the endoplasmic reticulum. Lipschutz, J.H., Lingappa, V.R., Mostov, K.E. J. Biol. Chem. (2003) [Pubmed]
  3. Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteins. Lipschutz, J.H., Guo, W., O'Brien, L.E., Nguyen, Y.H., Novick, P., Mostov, K.E. Mol. Biol. Cell (2000) [Pubmed]
  4. Dominant negative alleles of SEC10 reveal distinct domains involved in secretion and morphogenesis in yeast. Roth, D., Guo, W., Novick, P. Mol. Biol. Cell (1998) [Pubmed]
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