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Gene Review:

COQ9 - Coq9p

Saccharomyces cerevisiae S288c

Synonyms: Ubiquinone biosynthesis protein COQ9, mitochondrial, YLR201C

Johnson, A. et al., Tran, U.C. et al.

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High impact information on COQ9

In the budding yeast Saccharomyces cerevisiae, Q biosynthesis requires nine Coq proteins (Coq1-Coq9) [1].
The respiratory defect of C92 is complemented by COQ9 and suppressed by COQ8/ABC1 [2].
COQ9, a new gene required for the biosynthesis of coenzyme Q in Saccharomyces cerevisiae [2].
The mutant was used to clone COQ9, corresponding to reading frame YLR201c on chromosome XII [2].
Here, we report a new gene designated COQ9 that is also required for the biosynthesis of this lipoid quinone [2].

Other interactions of COQ9

Suppression by COQ8/ABC1 of C92, but not other coq9 mutants tested, has been related to an increase in the mitochondrial concentration of several enzymes of the pathway [2].

References

Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis. Tran, U.C., Marbois, B., Gin, P., Gulmezian, M., Jonassen, T., Clarke, C.F. J. Biol. Chem. (2006) [Pubmed]
COQ9, a new gene required for the biosynthesis of coenzyme Q in Saccharomyces cerevisiae. Johnson, A., Gin, P., Marbois, B.N., Hsieh, E.J., Wu, M., Barros, M.H., Clarke, C.F., Tzagoloff, A. J. Biol. Chem. (2005) [Pubmed]

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