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Gene Review

COQ1  -  trans-hexaprenyltranstransferase

Saccharomyces cerevisiae S288c

Synonyms: HPS, Hexaprenyl pyrophosphate synthase, mitochondrial, YBR003W, YBR0109
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High impact information on COQ1

  • In the budding yeast Saccharomyces cerevisiae, Q biosynthesis requires nine Coq proteins (Coq1-Coq9) [1].
  • We find that steady-state levels of Coq3p, Coq4p, and Coq6p are rescued in some cases to near wild-type levels by the presence of these diverse Coq1 orthologs in the Deltacoq1 mutant [2].
  • Genetic evidence for a multi-subunit complex in coenzyme Q biosynthesis in yeast and the role of the Coq1 hexaprenyl diphosphate synthase [2].
  • In Saccharomyces cerevisiae, the enzymes responsible for the assembly of the polyisoprenoid side chain and subsequent transfer to para-hydroxybenzoate (PHB) are encoded by the nuclear genes COQ1 and COQ2, respectively [3].
  • The sequence from the right arm includes a gene that probably encodes a novel trehalase, as well as the COQ1 gene (for an enzyme involved in coenzyme Q biosynthesis), and an open reading frame with significant similarity to bacterial genes of unknown function [4].

Biological context of COQ1


Associations of COQ1 with chemical compounds


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