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Gene Review

CLB4  -  Clb4p

Saccharomyces cerevisiae S288c

Synonyms: G2/mitotic-specific cyclin-4, L8167.3, YLR210W
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High impact information on CLB4

  • Thus, Clb4/Cdc28 prevents Kar9 loading on the mother bound pole [1].
  • Three of these (CLB1, CLB2, and CLB4) encode proteins strongly homologous to G2-specific B-type cyclins [2].
  • Cdk1-Clb4 controls the interaction of astral microtubule plus ends with subdomains of the daughter cell cortex [3].
  • Clb5 also has a function, along with Clb3 and Clb4, in the formation of mitotic spindles [4].
  • Because the cell cycle machinery participates in Saccharomyces cerevisiae filamentous growth, we characterized in detail the two C. albicans B-type cyclins, CLB2 and CLB4, to better understand the molecular mechanisms that underlie the C. albicans morphogenic switch [5].

Biological context of CLB4

  • CLB1 and CLB4 seem to be much more important for meiosis than for mitosis and may play some special role in meiosis II [6].
  • In contrast, SBF dissociates from the CLN2 promoter when transcription is repressed during G2 and M phases, suggesting that Clb1-Clb4 repress SBF activity by inhibiting its DNA-binding activity [7].
  • Coincidentally with reaching the bud cortex in S phase, Cdc28-Clb4 facilitates the dissociation of the microtubule bud tip interaction and their capture by the bud neck [3].

Anatomical context of CLB4


Other interactions of CLB4


  1. Asymmetric loading of Kar9 onto spindle poles and microtubules ensures proper spindle alignment. Liakopoulos, D., Kusch, J., Grava, S., Vogel, J., Barral, Y. Cell (2003) [Pubmed]
  2. The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae. Surana, U., Robitsch, H., Price, C., Schuster, T., Fitch, I., Futcher, A.B., Nasmyth, K. Cell (1991) [Pubmed]
  3. Cdk1-Clb4 controls the interaction of astral microtubule plus ends with subdomains of the daughter cell cortex. Maekawa, H., Schiebel, E. Genes Dev. (2004) [Pubmed]
  4. CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae. Schwob, E., Nasmyth, K. Genes Dev. (1993) [Pubmed]
  5. The mitotic cyclins Clb2p and Clb4p affect morphogenesis in Candida albicans. Bensen, E.S., Clemente-Blanco, A., Finley, K.R., Correa-Bordes, J., Berman, J. Mol. Biol. Cell (2005) [Pubmed]
  6. Specialization of B-type cyclins for mitosis or meiosis in S. cerevisiae. Dahmann, C., Futcher, B. Genetics (1995) [Pubmed]
  7. Switching transcription on and off during the yeast cell cycle: Cln/Cdc28 kinases activate bound transcription factor SBF (Swi4/Swi6) at start, whereas Clb/Cdc28 kinases displace it from the promoter in G2. Koch, C., Schleiffer, A., Ammerer, G., Nasmyth, K. Genes Dev. (1996) [Pubmed]
  8. Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2. Richardson, H., Lew, D.J., Henze, M., Sugimoto, K., Reed, S.I. Genes Dev. (1992) [Pubmed]
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