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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RSA3  -  Rsa3p

Saccharomyces cerevisiae S288c

Synonyms: Ribosome assembly protein 3, YLR221C
 
 
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High impact information on RSA3

  • Furthermore, coimmunoprecipitation and gel filtration analyses demonstrated that at least Npa2p, Dbp6p, Npa1p, Nop8p, and Rsa3p are present together in a subcomplex of low molecular mass whose integrity is independent of RNA [1].
  • Moreover, Rsa3p is co-immunoprecipitated with protA-tagged Dbp6p under low salt conditions [2].
  • The nonessential Rsa3p is a predominantly nucleolar protein required for optimal biogenesis of 60S ribosomal subunits [2].
  • The putative RNA helicase Dbp6p functionally interacts with Rpl3p, Nop8p and the novel trans-acting Factor Rsa3p during biogenesis of 60S ribosomal subunits in Saccharomyces cerevisiae [2].
 

Anatomical context of RSA3

  • We conclude that Npa1p is required for ribosome biogenesis and operates in the same functional environment of Rsa3p and Dbp6p during early maturation of 60S ribosomal subunits [3].
 

Other interactions of RSA3

  • Both Dbp6p and Rsa3p are associated with complexes that most likely correspond to early pre-60S ribosomal particles [2].

References

  1. Characterization of Saccharomyces cerevisiae Npa2p (Urb2p) Reveals a Low-Molecular-Mass Complex Containing Dbp6p, Npa1p (Urb1p), Nop8p, and Rsa3p Involved in Early Steps of 60S Ribosomal Subunit Biogenesis. Rosado, I.V., Dez, C., Lebaron, S., Caizergues-Ferrer, M., Henry, Y., de la Cruz, J. Mol. Cell. Biol. (2007) [Pubmed]
  2. The putative RNA helicase Dbp6p functionally interacts with Rpl3p, Nop8p and the novel trans-acting Factor Rsa3p during biogenesis of 60S ribosomal subunits in Saccharomyces cerevisiae. de la Cruz, J., Lacombe, T., Deloche, O., Linder, P., Kressler, D. Genetics (2004) [Pubmed]
  3. Npa1p is an essential trans-acting factor required for an early step in the assembly of 60S ribosomal subunits in Saccharomyces cerevisiae. Rosado, I.V., de la Cruz, J. RNA (2004) [Pubmed]
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