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Gene Review

BUR2  -  Bur2p

Saccharomyces cerevisiae S288c

Synonyms: Bypass UAS requirement protein 2, CST4, Chromosome stability protein 4, Protein BUR2, YLR226W
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High impact information on BUR2

  • This pathway apparently acts to negatively regulate transcription because deleting the genes for Set2 or Rpd3C(S) bypasses the requirement for the positive elongation factor Bur1/Bur2 [1].
  • Employing our global proteomic screen, GPS, we have determined that the loss of Bur2, a component of the Bur1/Bur2 cyclin-dependent protein kinase, results in a decrease in histone H3(K4) methylation catalyzed by COMPASS [2].
  • Activation of the Bur1-Bur2 cyclin-dependent kinase complex by Cak1 [3].
  • Synthetic genetic array (SGA) and transcription microarray analyses of a BUR2 mutant revealed that BUR is functionally similar to the PAF, Rad6, and Set1 complexes [4].

Biological context of BUR2

  • These results establish links between a regulatory protein kinase and histone methylation and lead to a model in which the Bur1-Bur2 complex counteracts an inhibitory effect of Set2-dependent histone methylation [5].
  • In Saccharomyces cerevisiae, Bur1 and Bur2 comprise a Cdk complex that is involved in transcriptional regulation, presumably mediated by its phosphorylation of the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II [3].

Physical interactions of BUR2

  • Bur1/Bur2 and the Ctk complex in yeast: the split personality of mammalian P-TEFb [6].

Other interactions of BUR2

  • BUR1 and BUR2 encode the catalytic and regulatory subunits of a cyclin-dependent protein kinase complex that is essential for normal growth and has a general role in transcription elongation [5].
  • In the yeast Saccharomyces cerevisiae, the cyclin dependent kinases Bur1/Bur2 and Ctk complex (Ctk1, 2 and 3) are also able to impact several aspects of transcription [6].

Analytical, diagnostic and therapeutic context of BUR2


  1. Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Keogh, M.C., Kurdistani, S.K., Morris, S.A., Ahn, S.H., Podolny, V., Collins, S.R., Schuldiner, M., Chin, K., Punna, T., Thompson, N.J., Boone, C., Emili, A., Weissman, J.S., Hughes, T.R., Strahl, B.D., Grunstein, M., Greenblatt, J.F., Buratowski, S., Krogan, N.J. Cell (2005) [Pubmed]
  2. The Bur1/Bur2 complex is required for histone H2B monoubiquitination by Rad6/Bre1 and histone methylation by COMPASS. Wood, A., Schneider, J., Dover, J., Johnston, M., Shilatifard, A. Mol. Cell (2005) [Pubmed]
  3. Activation of the Bur1-Bur2 cyclin-dependent kinase complex by Cak1. Yao, S., Prelich, G. Mol. Cell. Biol. (2002) [Pubmed]
  4. BUR kinase selectively regulates H3 K4 trimethylation and H2B ubiquitylation through recruitment of the PAF elongation complex. Laribee, R.N., Krogan, N.J., Xiao, T., Shibata, Y., Hughes, T.R., Greenblatt, J.F., Strahl, B.D. Curr. Biol. (2005) [Pubmed]
  5. The BUR1 cyclin-dependent protein kinase is required for the normal pattern of histone methylation by SET2. Chu, Y., Sutton, A., Sternglanz, R., Prelich, G. Mol. Cell. Biol. (2006) [Pubmed]
  6. Bur1/Bur2 and the Ctk complex in yeast: the split personality of mammalian P-TEFb. Wood, A., Shilatifard, A. Cell Cycle (2006) [Pubmed]
  7. BUR1 and BUR2 encode a divergent cyclin-dependent kinase-cyclin complex important for transcription in vivo. Yao, S., Neiman, A., Prelich, G. Mol. Cell. Biol. (2000) [Pubmed]
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