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Gene Review

CDD1  -  cytidine deaminase

Saccharomyces cerevisiae S288c

Synonyms: CDA, Cytidine aminohydrolase, Cytidine deaminase, L9672.13, YLR245C
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High impact information on CDD1

  • CDD1 is a yeast ortholog of APOBEC-1 that exhibits cytidine deaminase and RNA-editing activity [1].
  • The A. aeolicus TadA dimeric structure is completely different from the tetrameric structure of yeast CDD1, which deaminates mRNA and cytidine, but is similar to the dimeric structure of yeast cytosine deaminase [2].
  • The catalytic subunit APOBEC-1 is a cytidine deaminase and requires a second essential component recently cloned and termed APOBEC-1 complementing factor (ACF) or APOBEC-1-stimulating protein (ASP) [3].
  • By introduction of the polymorphic HCDA genes into the yeast CDA-null mutants, the HCDA-70T showed 40% and 32% activity of prototype for cytidine and ara-C substrates, respectively (P < 0.01) [4].

Associations of CDD1 with chemical compounds


  1. The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1. Xie, K., Sowden, M.P., Dance, G.S., Torelli, A.T., Smith, H.C., Wedekind, J.E. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Crystal structure of tRNA adenosine deaminase (TadA) from Aquifex aeolicus. Kuratani, M., Ishii, R., Bessho, Y., Fukunaga, R., Sengoku, T., Shirouzu, M., Sekine, S., Yokoyama, S. J. Biol. Chem. (2005) [Pubmed]
  3. Reconstitution of mRNA editing in yeast using a Gal4-apoB-Gal80 fusion transcript as the selectable marker. Lellek, H., Welker, S., Diehl, I., Kirsten, R., Greeve, J. J. Biol. Chem. (2002) [Pubmed]
  4. A functional single-nucleotide polymorphism in the human cytidine deaminase gene contributing to ara-C sensitivity. Yue, L., Saikawa, Y., Ota, K., Tanaka, M., Nishimura, R., Uehara, T., Maeba, H., Ito, T., Sasaki, T., Koizumi, S. Pharmacogenetics (2003) [Pubmed]
  5. New insights into the pyrimidine salvage pathway of Saccharomyces cerevisiae: requirement of six genes for cytidine metabolism. Kurtz, J.E., Exinger, F., Erbs, P., Jund, R. Curr. Genet. (1999) [Pubmed]
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