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Gene Review:

MDM30 - SCF ubiquitin ligase complex subunit MDM30

Saccharomyces cerevisiae S288c

Synonyms: Mitochondrial distribution and morphology protein 30, YLR368W

Dürr, M. et al., Fritz, S. et al., Muratani, M. et al., Neutzner, A. et al.

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High impact information on MDM30

The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing [1].
In contrast, mitochondria in mutants lacking Mdm30 are highly fragmented due to a defect in mitochondrial fusion [2].
Mitochondrial fusion is also blocked during sporulation of homozygous diploid mutants lacking Mdm30, leading to a mitochondrial inheritance defect in ascospores [2].
However, deletion of MDM30 did not stabilize Fzo1 after mating pheromone treatment, showing a different mechanism from the previously reported process of steady state Fzo1 regulation [3].
Our results suggest that Mdm30 controls mitochondrial shape by regulating the steady-state level of Fzo1 and point to a connection of the ubiquitin/26S proteasome system and mitochondria [4].

Biological context of MDM30

We propose that mitochondria-associated F-box proteins Mfb1 and Mdm30 are key components of a complex machinery that regulates mitochondrial dynamics throughout yeast's entire life cycle [2].

Anatomical context of MDM30

A fraction of Mdm30 is associated with mitochondria [4].

Other interactions of MDM30

Destruction of transcriptionally active Gal4 depends on an F box protein called Dsg1/Mdm30 [1].

References

The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing. Muratani, M., Kung, C., Shokat, K.M., Tansey, W.P. Cell (2005) [Pubmed]
Nonredundant roles of mitochondria-associated F-box proteins Mfb1 and Mdm30 in maintenance of mitochondrial morphology in yeast. Dürr, M., Escobar-Henriques, M., Merz, S., Geimer, S., Langer, T., Westermann, B. Mol. Biol. Cell (2006) [Pubmed]
Instability of the mitofusin Fzo1 regulates mitochondrial morphology during the mating response of the yeast Saccharomyces cerevisiae. Neutzner, A., Youle, R.J. J. Biol. Chem. (2005) [Pubmed]
Mdm30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. Fritz, S., Weinbach, N., Westermann, B. Mol. Biol. Cell (2003) [Pubmed]

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