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Gene Review

VMA6  -  H(+)-transporting V0 sector ATPase subunit d

Saccharomyces cerevisiae S288c

Synonyms: L9324.8, V-ATPase 39 kDa subunit, V-ATPase subunit M39, V-ATPase subunit d, V-type proton ATPase subunit d, ...
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High impact information on VMA6

  • Thus, the C subunit (homologue of d subunit, yeast Vma6p) associates with the L subunit ring tightly, and I (homologue of 100-kDa subunit, yeast Vph1p), E, and G subunits constitute a stable complex [1].
  • Vma6p was removed from wild type vacuolar membranes by strong chaotropic agents such as alkaline Na2CO3 or 5M urea, which did not remove integral membrane polypeptides [2].

Anatomical context of VMA6

  • In yeast cells lacking the integral membrane portion of the V-ATPase complex, Vma6p was unable to stably associate with vacuolar membranes [2].

Analytical, diagnostic and therapeutic context of VMA6

  • A 44-kD polypeptide cofractionated with V-ATPases upon gel-filtration chromatography of detergent-solubilized tonoplast membranes and was specifically cross-reactive with anti-Vma6p polyclonal antibodies [3].


  1. Subunit arrangement in V-ATPase from Thermus thermophilus. Yokoyama, K., Nagata, K., Imamura, H., Ohkuma, S., Yoshida, M., Tamakoshi, M. J. Biol. Chem. (2003) [Pubmed]
  2. The Saccharomyces cerevisiae VMA6 gene encodes the 36-kDa subunit of the vacuolar H(+)-ATPase membrane sector. Bauerle, C., Ho, M.N., Lindorfer, M.A., Stevens, T.H. J. Biol. Chem. (1993) [Pubmed]
  3. Characterization of a red beet protein homologous to the essential 36-kilodalton subunit of the yeast V-type ATPase. Bauerle, C., Magembe, C., Briskin, D.P. Plant Physiol. (1998) [Pubmed]
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