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Gene Review

ATP6V0D1  -  ATPase, H+ transporting, lysosomal 38kDa,...

Homo sapiens

Synonyms: 32 kDa accessory protein, ATP6D, ATP6DV, P39, V-ATPase 40 kDa accessory protein, ...
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Disease relevance of ATP6V0D1

  • P39 and P43, carrying both Pre-S(1) and Pre-S(2) sequences, were contained abundantly in Dane and tubular particles, and to a much lesser extent in small spherical particles, all of which were purified from plasma containing hepatitis B e antigen (HBeAg) [1].
  • In addition, anti-desialylated gp160 antibodies retained on a P39 affinity column still bound HIV-2 gp140 [2].
  • The molecular and antigenic variabilities of BmpA (P39) among European isolates of Borrelia burgdorferi were analyzed [3].
  • Ninety-four serum specimens from patients having Lyme borreliosis were tested for reactivity with P39 [4].
  • Analysis of Leptospira spp., Leptonema illini, and Rickettsia rickettsii for the 39-kilodalton antigen (P39) of Borrelia burgdorferi [5].

High impact information on ATP6V0D1

  • Due to their presence in Dane particles and the expression of a polyalbumin receptor, the immune responses against P39 and P43 may have significance in infection with hepatitis B virus and its immunoprophylaxis [6].
  • Caspase-3 activation by lysosomal enzymes in cytochrome c-independent apoptosis in myelodysplastic syndrome-derived cell line P39 [7].
  • However, we found that etoposide induced apoptosis in P39 cells, a myelodysplastic syndrome-derived cell line, without the release of cytochrome c. Furthermore, in etoposide-treated P39 cells, no changes in mitochondrial membrane potential (delta psi m) were detected by flow cytometry [7].
  • In conclusion, we have shown that mutant RAS promotes differentiation-associated cell death in P39 cells by stimulating the activity of PKC, which is itself an important regulator of myeloid differentiation [8].
  • P31 and P39 showed higher activities for poly-HSA receptor than their glycosylated versions [1].

Biological context of ATP6V0D1

  • It is suggested that the 40S RNP particle not only stores 5S RNA and tRNA but also provides a means for the exchange of the 5S RNA transcript binding protein (P45) for the 5S RNA ribosome associated protein (P39) [9].
  • Phosphorylation of P39 and P50 correlated better with PGI2-induced inhibition of platelet activation [10].
  • The activity of the P39 promoter was measured in HeLa or EL-4 cells transfected with these clones, either by an RNase protection assay or by following the expression of a reporter gene, CAT (which codes for chloramphenicol acetyltransferase), placed under the control of this promoter [11].
  • A polypeptide (polypeptide P39), which is presumed to involved in the photosynthetic circadian rhythm in the green alga Acetabularia, was purified from the EDTA-insoluble chloroplast membrane fraction by means of preparative dodecylsulfate gel electrophoresis and then partially characterized [12].
  • In routine recordings of tibial nerve somatosensory evoked potentials (SEPs), a global central conduction time is evaluated by measuring the interval between the segmental spinal N22 potential, recorded in the lumbar region, and the cortical P39 potential [13].

Anatomical context of ATP6V0D1

  • HU also enhanced the differentiation of other myeloid leukaemia HL-60, ML-1, THP-1, P39/TSU, P31/FUJ and NB4 cells induced by 1,25(OH)2D3 and that of U937 cells induced by 24-epi-1,25(OH)2D2 and 1,25(OH)2D7 [14].
  • The growth of two non-T,non-B-cell lines (Reh, P30/OHK) and six myeloid cell lines (ML-1, U937, THP-1-0, P31/FUJ, P39/TSU, HEL) was found to be significantly inhibited by a 72 hr treatment with PAC-4D [15].
  • Non-lipidated spirochetal antigens (OspA, OspC and P39) including those selectively expressed in the mammalian host (pG and BapA) were used for antigenic stimulation and autologous dendritic cells served as antigen-presenting cells [16].
  • Conduction in the optic nerve was recorded prior to P39, by which time responses from the superior colliculus appeared [17].
  • Our results show that bone marrow is more sensitive to this process than either myelomonocytoid leukemic P39 or Jurkat T-lymphocyte cell lines [18].

Associations of ATP6V0D1 with chemical compounds

  • Interestingly, 1alpha(OH)D derivatives (1alpha-hydroxyvitamin D3, D2, D4 and D7) effectively induced the differentiation of monoblastic leukaemia U937, P39/TSU and P31/FUJ cells [14].
  • We propose that RA-treated P39 differentiation model is ideally suited for the study of MDS [19].
  • As evaluated by characteristic morphological changes and oligonucleosomal lengths DNA ladder, the levels of apoptosis in P39 cells induced by actinomycin D, or A23187, were far greater than in other myeloid lines examined in this study [19].
  • The purity of the isolated polypeptide P39 was confirmed by a further electrophoresis on an analytical dodecylsulfate gel and further elucidated by amino-terminal analysis which shows that glycine is the only amino-terminal amino acid of the purified polypeptide material [12].
  • Averaged over five inbreds (De811, Ia5125, Mo17, P39, and Wh8584), lower leaf blades had higher levels of xylose and lower levels of total uronosyls, glucose, arabinose, and galactose (P < 0.05) than did upper leaf blades [20].

Other interactions of ATP6V0D1


Analytical, diagnostic and therapeutic context of ATP6V0D1

  • Heterogeneity of BmpA (P39) among European isolates of Borrelia burgdorferi sensu lato and influence of interspecies variability on serodiagnosis [3].
  • Therefore, antibody to P39 could be mistaken for antibody to the 41-kDa flagellin in tests of human sera by Western blot (immunoblot) [4].
  • The molecular weight of the polypeptide P39 was found to be about 39,000 on analytical gel electrophoresis and the value was further supported by those obtained from amino acid composition and peptide mapping [12].
  • Detection of antibodies to the recombinant P39 protein of Borrelia burgdorferi using enzyme immunoassay and immunoblotting [22].
  • However, using a highly specific enzyme-linked immunosorbent assay based on two recombinant outer antigens encoded by C. jejuni genes Cj0017 (P39) and Cj0113 (P18), we found serological evidence of a preceding C. jejuni infection in 80.6% of the patients but in only 3.5% of the controls [23].


  1. Polypeptides coded for by the region pre-S and gene S of hepatitis B virus DNA with the receptor for polymerized human serum albumin: expression on hepatitis B particles produced in the HBeAg or anti-HBe phase of hepatitis B virus infection. Takahashi, K., Kishimoto, S., Ohnuma, H., Machida, A., Takai, E., Tsuda, F., Miyamoto, H., Tanaka, T., Matsushita, K., Oda, K. J. Immunol. (1986) [Pubmed]
  2. Specificity of antibodies produced against native or desialylated human immunodeficiency virus type 1 recombinant gp160. Benjouad, A., Gluckman, J.C., Montagnier, L., Bahraoui, E. J. Virol. (1993) [Pubmed]
  3. Heterogeneity of BmpA (P39) among European isolates of Borrelia burgdorferi sensu lato and influence of interspecies variability on serodiagnosis. Roessler, D., Hauser, U., Wilske, B. J. Clin. Microbiol. (1997) [Pubmed]
  4. Reactivity of human Lyme borreliosis sera with a 39-kilodalton antigen specific to Borrelia burgdorferi. Simpson, W.J., Schrumpf, M.E., Schwan, T.G. J. Clin. Microbiol. (1990) [Pubmed]
  5. Analysis of Leptospira spp., Leptonema illini, and Rickettsia rickettsii for the 39-kilodalton antigen (P39) of Borrelia burgdorferi. Schwan, T.G., Schrumpf, M.E., Gage, K.L., Gilmore, R.D. J. Clin. Microbiol. (1992) [Pubmed]
  6. Large hepatitis B surface antigen polypeptides of Dane particles with the receptor for polymerized human serum albumin. Ohnuma, H., Takahashi, K., Kishimoto, S., Machida, A., Imai, M., Mishiro, S., Usuda, S., Oda, K., Nakamura, T., Miyakawa, Y. Gastroenterology (1986) [Pubmed]
  7. Caspase-3 activation by lysosomal enzymes in cytochrome c-independent apoptosis in myelodysplastic syndrome-derived cell line P39. Hishita, T., Tada-Oikawa, S., Tohyama, K., Miura, Y., Nishihara, T., Tohyama, Y., Yoshida, Y., Uchiyama, T., Kawanishi, S. Cancer Res. (2001) [Pubmed]
  8. Mutant RAS selectively promotes sensitivity of myeloid leukemia cells to apoptosis by a protein kinase C-dependent process. Gallagher, A.P., Burnett, A.K., Bowen, D.T., Darley, R.L. Cancer Res. (1998) [Pubmed]
  9. Analysis of reconstruction of an RNP particle which stores 5S RNA and tRNA in amphibian oocytes. Kloetzel, P.M., Whitfield, W., Sommerville, J. Nucleic Acids Res. (1981) [Pubmed]
  10. Functional relationship between cyclic AMP-dependent protein phosphorylation and platelet inhibition. Siess, W., Lapetina, E.G. Biochem. J. (1990) [Pubmed]
  11. Minute virus of mice non-structural protein NS-1 is necessary and sufficient for trans-activation of the viral P39 promoter. Doerig, C., Hirt, B., Beard, P., Antonietti, J.P. J. Gen. Virol. (1988) [Pubmed]
  12. The role of chloroplast-membrane-protein synthesis in the circadian clock. Purification and partial characterization of a polypeptide which is suggested to be involved in the clock. Leong, T.Y., Schweiger, H.G. Eur. J. Biochem. (1979) [Pubmed]
  13. Assessment of intraspinal and intracranial conduction by P30 and P39 tibial nerve somatosensory evoked potentials in cervical cord, brainstem, and hemispheric lesions. Tinazzi, M., Mauguière, F. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. (1995) [Pubmed]
  14. Growth inhibition and differentiation induction in human monoblastic leukaemia cells by 1alpha-hydroxyvitamin D derivatives and their enhancement by combination with hydroxyurea. Makishima, M., Okabe-Kado, J., Honma, Y. Br. J. Cancer (1998) [Pubmed]
  15. Potential limitation of growth-inhibitory action of recombinant human tumor necrosis factor (PAC-4D) due to easy induction of resistance: evidence in vitro. Hanada, M., Shimoyama, M. Jpn. J. Cancer Res. (1987) [Pubmed]
  16. Prominent T cell response to a selectively in vivo expressed Borrelia burgdorferi outer surface protein (pG) in patients with Lyme disease. Bauer, Y., Hofmann, H., Jahraus, O., Mytilineos, J., Simon, M.M., Wallich, R. Eur. J. Immunol. (2001) [Pubmed]
  17. Development of functional connections between thalamic fibres and the visual cortex of the wallaby revealed by current source density analysis in vivo. Pearce, A.R., James, A.C., Mark, R.F. J. Comp. Neurol. (2000) [Pubmed]
  18. Freezing induces artificial cleavage of apoptosis-related proteins in human bone marrow cells. Schmidt-Mende, J., Hellström-Lindberg, E., Joseph, B., Zhivotovsky, B. J. Immunol. Methods (2000) [Pubmed]
  19. Marked apoptosis of human myelomonocytic leukemia cell line P39: significance of cellular differentiation. Anzai, N., Kawabata, H., Hirama, T., Masutani, H., Ohmori, M., Yoshida, Y., Okuma, M. Leukemia (1994) [Pubmed]
  20. Cell wall composition in juvenile and adult leaves of maize (Zea mays L.). Abedon, B.G., Hatfield, R.D., Tracy, W.F. J. Agric. Food Chem. (2006) [Pubmed]
  21. Structure of the VPATPD gene encoding subunit D of the human vacuolar proton ATPase. Agarwal, A.K., White, P.C. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  22. Detection of antibodies to the recombinant P39 protein of Borrelia burgdorferi using enzyme immunoassay and immunoblotting. Fawcett, P.T., Rose, C., Gibney, K.M., Chase, C.A., Kiehl, B., Doughty, R.A. J. Rheumatol. (1993) [Pubmed]
  23. Improved serological diagnosis stresses the major role of Campylobacter jejuni in triggering Guillain-Barré syndrome. Schmidt-Ott, R., Schmidt, H., Feldmann, S., Brass, F., Krone, B., Gross, U. Clin. Vaccine Immunol. (2006) [Pubmed]
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