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Gene Review

Atp6v0d1  -  ATPase, H+ transporting, lysosomal V0...

Mus musculus

Synonyms: AI267038, Ac39, Atp6d, P39, Physophilin, ...
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Disease relevance of Atp6v0d1


High impact information on Atp6v0d1


Biological context of Atp6v0d1


Anatomical context of Atp6v0d1

  • We have cloned physophilin from mouse brain and found a differential region of 12 amino acids when compared with the previously reported sequence of Ac39 from bovine adrenal medulla [4].

Other interactions of Atp6v0d1

  • Because of its affinity for synaptophysin, we named the 36-kD synaptic vesicle-binding protein physophilin (psi nu sigma alpha, greek = bubble, vesicle; psi iota lambda os, greek = friend) [3].

Analytical, diagnostic and therapeutic context of Atp6v0d1

  • In situ hybridization in rat brain reveals a largely neuronal distribution of Ac39/physophilin mRNA which spatio-temporally correlates with those of subunit c and synaptophysin [4].
  • PROCEDURE--Serologic responses to B burgdorferi and recombinant outer surface protein (Osp)A, flagellin, and P39 were assessed by means of ELISA and western immunoblot [6].


  1. Outer surface protein C (OspC), but not P39, is a protective immunogen against a tick-transmitted Borrelia burgdorferi challenge: evidence for a conformational protective epitope in OspC. Gilmore, R.D., Kappel, K.J., Dolan, M.C., Burkot, T.R., Johnson, B.J. Infect. Immun. (1996) [Pubmed]
  2. Induction of immune response in BALB/c mice with a DNA vaccine encoding bacterioferritin or P39 of Brucella spp. Al-Mariri, A., Tibor, A., Mertens, P., De Bolle, X., Michel, P., Godfroid, J., Walravens, K., Letesson, J.J. Infect. Immun. (2001) [Pubmed]
  3. Synaptophysin binds to physophilin, a putative synaptic plasma membrane protein. Thomas, L., Betz, H. J. Cell Biol. (1990) [Pubmed]
  4. Brain Ac39/physophilin: cloning, coexpression and colocalization with synaptophysin. Carrión-Vázquez, M., Fernández, A.M., Chowen, J., Nieto-Sampedro, M. Eur. J. Neurosci. (1998) [Pubmed]
  5. The d subunit of the vacuolar ATPase (Atp6d) is essential for embryonic development. Miura, G.I., Froelick, G.J., Marsh, D.J., Stark, K.L., Palmiter, R.D. Transgenic Res. (2003) [Pubmed]
  6. Serologic responses of dogs naturally exposed to or vaccinated against Borrelia burgdorferi infection. Barthold, S.W., Levy, S.A., Fikrig, E., Bockenstedt, L.K., Smith, A.L. J. Am. Vet. Med. Assoc. (1995) [Pubmed]
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