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Gene Review

ATP6V0D1  -  ATPase, H+ transporting, lysosomal 38kDa,...

Bos taurus

Synonyms: ATP6D, ATP6DV
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Disease relevance of ATP6D

  • Monoclonal antibodies and polyclonal antisera recognizing a 39-kDa protein (P39) of brucellin, a cytoplasmic extract from Brucella melitensis rough strain B115, were produced [1].
  • Eleven of fourteen Brucella-infected cows whose infections had been detected by the delayed-type hypersensitivity (DTH) test with brucellergen also developed a DTH reaction when purified P39 was used as the trigger [1].

High impact information on ATP6D

  • The T-cell proliferative responses to P39 of peripheral blood lymphocytes from Brucella-infected cows were also positive [1].
  • The nucleotide sequence of the P39 gene was determined, and the deduced amino acid sequence is in accordance with the sequence of an internal peptide isolated from P39 [1].
  • None of the animals infected with other bacterial species that are presumed to induce immunological cross-reactions with Brucella spp. reacted to P39, either in DTH tests or in lymphocyte proliferation assays [1].
  • A lambda gt11 genomic library of Brucella abortus was screened with a monoclonal antibody specific for P39, and the gene coding for this protein was subsequently isolated [1].


  1. Characterization, occurrence, and molecular cloning of a 39-kilodalton Brucella abortus cytoplasmic protein immunodominant in cattle. Denoel, P.A., Vo, T.K., Tibor, A., Weynants, V.E., Trunde, J.M., Dubray, G., Limet, J.N., Letesson, J.J. Infect. Immun. (1997) [Pubmed]
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