High impact information on ATS1

• Thus, we identified yeast open reading frames (ORFs) YBL071w-A and YAL020c/ATS1 as KTI11 and KTI13 respectively [1].
• The predicted ATS1 protein contains 333 amino acids and has considerable structural homology to the products of both the mammalian mitotic control gene RCC1 and the S. cerevisiae gene SRM1/PRP20 [2].
• Deletion of ATS1 confers a modest slow growth phenotype which is slightly enhanced in strains containing both a deletion of ATS1 and a class 2 tub 1 mutation [2].
• Saccharomyces cerevisiae Ats1p interacts with Nap1p, a cytoplasmic protein that controls bud morphogenesis [3].
• Our results suggest Ats1p might regulate coordination of the microtubule state with the cell cycle through an interaction with Nap1p [3].

Other interactions of ATS1

• Nap1p and Ats1p interact in two-hybrid and co-immunoprecipitation assays [3].

Analytical, diagnostic and therapeutic context of ATS1

• Both loci, KTI11 and KTI13, are actively transcribed protein-encoding genes as determined by reverse transcriptase-polymerase chain reaction (RT-PCR) and in vivo HA epitope tagging [1].

References