The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt

Table of contents

About

Terms

 

Gene Review: 

PPH22  -  phosphoprotein phosphatase 2A catalytic...

Saccharomyces cerevisiae S288c

Synonyms: D1271, SIS4, Serine/threonine-protein phosphatase PP2A-2 catalytic subunit, YDL188C
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on PPH22

  • Two genes (PPH21 and PPH22) encoding the yeast homologues of protein serine-threonine phosphatase 2A have been cloned from a Saccharomyces cerevisiae genomic library using a rabbit protein phosphatase 2A cDNA as a hybridization probe [1].
  • A disruption of the third gene, PPH3, did not in itself affect growth, but it completely prevented growth of spores disrupted for both PPH21 and PPH22 [2].
  • In addition to cdc5-1, overexpression of CDC55, PPH21, or PPH22 is also toxic to other temperature-sensitive mutants that display defects in mitotic exit [3].
  • PPH22 overexpression mimics overactive cAMP-PKA (protein kinase A) signalling and PP2A and Sit4 might represent ceramide signalling targets [4].
  • Suppression of the lethal phenotype of the rrd1,2delta mutant by overexpression of PPH22 suggested that the products of the RRD genes function positively with catalytic subunits of PP2A [5].
 

Biological context of PPH22

References

  1. Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes. Sneddon, A.A., Cohen, P.T., Stark, M.J. EMBO J. (1990) [Pubmed]
  2. Protein phosphatase 2A in Saccharomyces cerevisiae: effects on cell growth and bud morphogenesis. Ronne, H., Carlberg, M., Hu, G.Z., Nehlin, J.O. Mol. Cell. Biol. (1991) [Pubmed]
  3. Phosphatase 2A negatively regulates mitotic exit in Saccharomyces cerevisiae. Wang, Y., Ng, T.Y. Mol. Biol. Cell (2006) [Pubmed]
  4. Protein phosphatase 2A on track for nutrient-induced signalling in yeast. Zabrocki, P., Van Hoof, C., Goris, J., Thevelein, J.M., Winderickx, J., Wera, S. Mol. Microbiol. (2002) [Pubmed]
  5. Functional analysis of RRD1 (YIL153w) and RRD2 (YPL152w), which encode two putative activators of the phosphotyrosyl phosphatase activity of PP2A in Saccharomyces cerevisiae. Rempola, B., Kaniak, A., Migdalski, A., Rytka, J., Slonimski, P.P., di Rago, J.P. Mol. Gen. Genet. (2000) [Pubmed]
  6. Overexpression of yeast PAM1 gene permits survival without protein phosphatase 2A and induces a filamentous phenotype. Hu, G.Z., Ronne, H. J. Biol. Chem. (1994) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities