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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ppa2  -  serine/threonine protein phosphatase Ppa2

Schizosaccharomyces pombe 972h-

 
 
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High impact information on ppa2

  • Two previously identified PP1 genes (dis2+ and sds21+) and two PP2A genes (ppa1+ and ppa2+), highly homologous to mammalian PP2A, have been isolated from fission yeast [1].
  • When a strain deleted for ppa2 is treated with okadaic acid, cell size is reduced further to that of wee1-50 mutant strain or overexpressing the cdc25+ gene product, suggesting functional relationship of ppa2 with the cdc25 tyrosine phosphatase and/or the wee1 kinase in cell cycle control [2].
  • Negative regulation of mitosis by the fission yeast protein phosphatase ppa2 [2].
  • Overproduced ppa1 or ppa2 proteins accumulate in the cytoplasm near the nuclear periphery, and cells arrest in interphase [2].
  • To understand the role of the type 2A-like protein phosphatase in the cell division cycle, we investigated the mutant phenotypes obtained when the fission yeast ppa1+ and ppa2+ phosphatase genes (which encode polypeptides with approximately 80% identity to mammalian type 2A phosphatases) were either deleted or overexpressed [2].
 

Biological context of ppa2

  • This semi-wee phenotype is enhanced in delta ppa2 mutants treated with the phosphatase inhibitor, okadaic acid [3].

References

  1. Distinct, essential roles of type 1 and 2A protein phosphatases in the control of the fission yeast cell division cycle. Kinoshita, N., Ohkura, H., Yanagida, M. Cell (1990) [Pubmed]
  2. Negative regulation of mitosis by the fission yeast protein phosphatase ppa2. Kinoshita, N., Yamano, H., Niwa, H., Yoshida, T., Yanagida, M. Genes Dev. (1993) [Pubmed]
  3. Protein phosphatases and cell division cycle control. Yanagida, M., Kinoshita, N., Stone, E.M., Yamano, H. Ciba Found. Symp. (1992) [Pubmed]
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