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Gene Review

PPP2CB  -  protein phosphatase 2, catalytic subunit,...

Homo sapiens

Synonyms: PP2A-beta, PP2Abeta, PP2CB, Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
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High impact information on PPP2CB

  • This low level of PP2A protein was reflected at a relative deficiency in expression of the PP2A beta gene in HL-60RAr cells [1].
  • The mRNA level of PP2A beta was markedly decreased within 5 h after addition of ATRA, but there was only a slight increase in the mRNA level of PP2A alpha [2].
  • Selective down-regulation of PP2A beta mRNA clearly preceded the cell differentiation induced by ATRA treatment [2].
  • Mutation analysis of 8p genes POLB and PPP2CB in bladder cancer [3].
  • Also mapped to this region (8p12-p11.2) is the gene encoding the beta isoform of the catalytic subunit of protein phosphatase 2A (PPP2CB), a major serine/threonine phosphatase thought to play a regulatory role in many cellular pathways [3].

Biological context of PPP2CB


Analytical, diagnostic and therapeutic context of PPP2CB


  1. Decreased expression of protein phosphatase type 2A in HL-60 variant (HL-60RAr) cells resistant to induction of cell differentiation by all-trans retinoic acid. Omay, S.B., Nishikawa, M., Morita, K., Toyoda, H., Nakai, K., Shima, H., Nagao, M., Kitagawa, S., Saito, M., Shiku, H. Exp. Hematol. (1995) [Pubmed]
  2. Down-regulation by retinoic acid of the catalytic subunit of protein phosphatase type 2A during granulocytic differentiation of HL-60 cells. Tawara, I., Nishikawa, M., Morita, K., Kobayashi, K., Toyoda, H., Omay, S.B., Shima, H., Nagao, M., Kuno, T., Tanaka, C. FEBS Lett. (1993) [Pubmed]
  3. Mutation analysis of 8p genes POLB and PPP2CB in bladder cancer. Eydmann, M.E., Knowles, M.A. Cancer Genet. Cytogenet. (1997) [Pubmed]
  4. Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively. Jones, T.A., Barker, H.M., da Cruz e Silva, E.F., Mayer-Jaekel, R.E., Hemmings, B.A., Spurr, N.K., Sheer, D., Cohen, P.T. Cytogenet. Cell Genet. (1993) [Pubmed]
  5. Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes resulting, in part, from the suppression of PP2A{alpha}. Bonness, K., Aragon, I.V., Rutland, B., Ofori-Acquah, S., Dean, N.M., Honkanen, R.E. Mol. Cancer Ther. (2006) [Pubmed]
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