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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PET100  -  Pet100p

Saccharomyces cerevisiae S288c

Synonyms: D4441, Protein PET100, mitochondrial, YDR079W
 
 
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High impact information on PET100

  • Previous studies have shown that Pet100p is not required for the synthesis, processing, or targeting of cytochrome c oxidase subunits to the mitochondrion nor for heme A biosynthesis [1].
  • We have also localized Pet100p to the inner mitochondrial membrane in wild type cells, where it is present in a subassembly (Complex A) with cytochrome c oxidase subunits VII, VIIa, and VIII [1].
  • PET100 is located adjacent to the PDC2 gene on chromosome IV and contains an open reading frame of 333 base pairs [2].
  • A strain carrying a null mutation in PET100 lacks cytochrome c oxidase activity and assembled cytochromes a and a3, but the other respiratory chain carriers are present [2].
  • The PET100 protein contains a possible membrane-spanning segment and a putative mitochondrial import sequence at its NH2 terminus [2].
 

Biological context of PET100

 

Anatomical context of PET100

  • In addition, mitochondria from the strain carrying a null mutation in PET100 contain each of the subunit polypeptides of cytochrome c oxidase [2].

References

  1. A role for Pet100p in the assembly of yeast cytochrome c oxidase: interaction with a subassembly that accumulates in a pet100 mutant. Church, C., Goehring, B., Forsha, D., Wazny, P., Poyton, R.O. J. Biol. Chem. (2005) [Pubmed]
  2. Cloning and characterization of PET100, a gene required for the assembly of yeast cytochrome c oxidase. Church, C., Chapon, C., Poyton, R.O. J. Biol. Chem. (1996) [Pubmed]
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