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Gene Review

PDC2  -  Pdc2p

Saccharomyces cerevisiae S288c

Synonyms: D4451, Protein PDC2, YDR081C
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High impact information on PDC2


Biological context of PDC2

  • Both are known to affect gene expression in an autoregulatory mechanism and expression of both is regulated by glucose and Pdc2, further pointing to a role of Pdc2 in coordinating different metabolic signals [5].
  • Using global and gene-specific expression analysis, we show that Pdc2 is required for the upregulation of all genes controlled by thiamine availability [5].
  • The PDC2 deletion mutant exhibits a phenotype very similar to, but more severe than that of the point mutant: a strongly reduced pyruvate decarboxylase specific activity, slow, respiration-dependent growth on glucose, and accumulation of pyruvate [6].
  • The amino acid sequence comparisons between CaPdc2p of C. albicans and both Pdc2p of Saccharomyces cerevisiae and Rag3p of Kluyveromyces lactis, revealed similarities of 40% and 39%, respectively [7].

Associations of PDC2 with chemical compounds

  • The Pdc2 has also been implicated as a regulator of genes encoding enzymes in ThDP metabolism [5].
  • Synthesis of pyruvate decarboxylase is regulated by PDC2 at the transcriptional level [6].

Regulatory relationships of PDC2


Other interactions of PDC2

  • The DNA binding protein Pdc2 was initially identified as a regulator of the genes PDC1 and PDC5, which encode isoforms of the glycolytic enzyme pyruvate decarboxylase (Pdc) [5].
  • The Pdc2 seems to act together with Thi2, a known transcriptional regulator of THI genes [5].
  • While the Thi2, in conjunction with Thi3, seems to control expression of THI genes with respect to thiamine availability, the Pdc2 may link the ThDP demand to carbon source availability [5].
  • In fact, the triple mutant gpp1 Delta gpp2 Delta pdc2 Delta overexpressing GPD1 accumulated 17 mg L-G3P/g dry weight during glucose batch fermentation under oxygen limitation [8].


  1. Cloning and characterization of PET100, a gene required for the assembly of yeast cytochrome c oxidase. Church, C., Chapon, C., Poyton, R.O. J. Biol. Chem. (1996) [Pubmed]
  2. Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae. Nosaka, K., Onozuka, M., Konno, H., Kawasaki, Y., Nishimura, H., Sano, M., Akaji, K. Mol. Microbiol. (2005) [Pubmed]
  3. RAG3 gene and transcriptional regulation of the pyruvate decarboxylase gene in Kluyveromyces lactis. Prior, C., Tizzani, L., Fukuhara, H., Wésolowski-Louvel, M. Mol. Microbiol. (1996) [Pubmed]
  4. Suppression of pdc2 regulating pyruvate decarboxylase synthesis in yeast. Velmurugan, S., Lobo, Z., Maitra, P.K. Genetics (1997) [Pubmed]
  5. Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae. Mojzita, D., Hohmann, S. Mol. Genet. Genomics (2006) [Pubmed]
  6. Characterisation of PDC2, a gene necessary for high level expression of pyruvate decarboxylase structural genes in Saccharomyces cerevisiae. Hohmann, S. Mol. Gen. Genet. (1993) [Pubmed]
  7. Identification of a gene encoding the pyruvate decarboxylase gene regulator CaPdc2p from Candida albicans. Kaiser, B., Munder, T., Saluz, H.P., Künkel, W., Eck, R. Yeast (1999) [Pubmed]
  8. Engineering of Saccharomyces cerevisiae for the production of L-glycerol 3-phosphate. Nguyen, H.T., Dieterich, A., Athenstaedt, K., Truong, N.H., Stahl, U., Nevoigt, E. Metab. Eng. (2004) [Pubmed]
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