Psychiatry related information on YDR107C

• Mutations in the two related genes, presenilin 1 (PS1) and presenilin 2 (PS2), which are predicted multispanning membrane proteins, are responsible for the majority of early-onset familial Alzheimer's disease (FAD) [1].

High impact information on YDR107C

• Cross-linking studies indicate that the signal sequence interacts in a Kar2p- and ATP-independent reaction with Sec61p, the multispanning membrane component of the protein-conducting channel, by intercalation into transmembrane domains 2 and 7 [2].
• Prm1p, a pheromone-regulated multispanning membrane protein, facilitates plasma membrane fusion during yeast mating [3].
• Ste6p, the a-factor transporter in Saccharomyces cerevisiae, is a multispanning membrane protein with 12 transmembrane spans and two cytosolic ATP binding domains [4].
• Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein [5].
• The multispanning membrane protein Ste24p catalyzes CAAX proteolysis and NH2-terminal processing of the yeast a-factor precursor [6].

Biological context of YDR107C

• Saccharomyces cerevisiae Ste24p is a multispanning membrane protein implicated in the CAAX proteolysis step that occurs during biogenesis of the prenylated a-factor mating pheromone [6].

Anatomical context of YDR107C

• The multispanning membrane protein Ste6, a member of the ABC-transporter family, is transported to the yeast vacuole for degradation [7].

Other interactions of YDR107C

• This uracil permease is a multispanning membrane protein that follows the secretory pathway to the plasma membrane [8].

References