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Gene Review

FUR4  -  Fur4p

Saccharomyces cerevisiae S288c

Synonyms: Uracil permease, YBR021W, YBR0303
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Disease relevance of FUR4

  • Among these, Tpn1, Fur4 and the one encoded by yOR071c were found to contribute significantly to 5-FC toxicity, thus revealing alternative entry routes for 5-FC via other cytosine/adenine permease homologues [1].
  • The uracil permease gene of the yeast Saccharomyces cerevisiae was cloned on a hybrid plasmid which replicates autonomously in both yeast and Escherichia coli [2].
  • Our results show that long chain bases do not contribute to the inactivation of Fur4p transport activity after heat stress, but they are essential for some later, but unknown, process that leads to degradation of the protein [3].

High impact information on FUR4


Biological context of FUR4


Anatomical context of FUR4


Associations of FUR4 with chemical compounds


Physical interactions of FUR4


Other interactions of FUR4

  • The ubiquitin-permease conjugates that are readily demonstrated in wild type cells were barely detectable in npi1 mutant cells, indicating that uracil permease may be a physiological substrate of the Npi1p ubiquitin ligase [8].
  • Thus, the growth inhibition by leflunomide seen in a S. cerevisiae ura3 auxotroph is due to the inhibition of the entry of exogenous uracil via the Fur4 uracil permease [16].
  • After the observation that FUR4 was closely linked to GAL10, one of the three genes forming the gal cluster (Bassel and Mortimer 1971), we could determine precisely the position of the gene on chromosome II [18].
  • Gap1p is thus ubiquitinated differently from the proteins targeted by ubiquitination for proteolysis by the proteasome, but in the same manner as the uracil permease, also subject to ubiquitin-dependent endocytosis [19].
  • These data suggest that Fur4p undergoes Doa4p-dependent deubiquitination prior to vacuolar degradation [20].

Analytical, diagnostic and therapeutic context of FUR4


  1. Various cytosine/adenine permease homologues are involved in the toxicity of 5-fluorocytosine in Saccharomyces cerevisiae. Paluszynski, J.P., Klassen, R., Rohe, M., Meinhardt, F. Yeast (2006) [Pubmed]
  2. Cloning and transcriptional control of a eucaryotic permease gene. Chevallier, M.R. Mol. Cell. Biol. (1982) [Pubmed]
  3. The uracil transporter Fur4p associates with lipid rafts. Hearn, J.D., Lester, R.L., Dickson, R.C. J. Biol. Chem. (2003) [Pubmed]
  4. Ubiquitin lys63 is involved in ubiquitination of a yeast plasma membrane protein. Galan, J.M., Haguenauer-Tsapis, R. EMBO J. (1997) [Pubmed]
  5. Expression of the cloned uracil permease gene of Saccharomyces cerevisiae in a heterologous membrane. Chevallier, M.R., Lacroute, F. EMBO J. (1982) [Pubmed]
  6. Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease. Bultynck, G., Heath, V.L., Majeed, A.P., Galan, J.M., Haguenauer-Tsapis, R., Cyert, M.S. Mol. Cell. Biol. (2006) [Pubmed]
  7. Genomic reorganization between two sibling yeast species, Saccharomyces bayanus and Saccharomyces cerevisiae. Ryu, S.L., Murooka, Y., Kaneko, Y. Yeast (1996) [Pubmed]
  8. Ubiquitination mediated by the Npi1p/Rsp5p ubiquitin-protein ligase is required for endocytosis of the yeast uracil permease. Galan, J.M., Moreau, V., Andre, B., Volland, C., Haguenauer-Tsapis, R. J. Biol. Chem. (1996) [Pubmed]
  9. The nucleotide sequence of TTP1, a gene encoding a predicted type II membrane protein. Romero, P.A., Athanassiadis, A., Lussier, M., Herscovics, A. Yeast (1994) [Pubmed]
  10. A PEST-like sequence mediates phosphorylation and efficient ubiquitination of yeast uracil permease. Marchal, C., Haguenauer-Tsapis, R., Urban-Grimal, D. Mol. Cell. Biol. (1998) [Pubmed]
  11. Membrane insertion of uracil permease, a polytopic yeast plasma membrane protein. Silve, S., Volland, C., Garnier, C., Jund, R., Chevallier, M.R., Haguenauer-Tsapis, R. Mol. Cell. Biol. (1991) [Pubmed]
  12. Direct sorting of the yeast uracil permease to the endosomal system is controlled by uracil binding and Rsp5p-dependent ubiquitylation. Blondel, M.O., Morvan, J., Dupré, S., Urban-Grimal, D., Haguenauer-Tsapis, R., Volland, C. Mol. Biol. Cell (2004) [Pubmed]
  13. Membrane topology of the yeast uracil permease. Garnier, C., Blondel, M.O., Haguenauer-Tsapis, R. Mol. Microbiol. (1996) [Pubmed]
  14. Casein kinase I-dependent phosphorylation within a PEST sequence and ubiquitination at nearby lysines signal endocytosis of yeast uracil permease. Marchal, C., Haguenauer-Tsapis, R., Urban-Grimal, D. J. Biol. Chem. (2000) [Pubmed]
  15. The ORF YBL042 of Saccharomyces cerevisiae encodes a uridine permease. Wagner, R., de Montigny, J., de Wergifosse, P., Souciet, J.L., Potier, S. FEMS Microbiol. Lett. (1998) [Pubmed]
  16. Growth inhibition of Saccharomyces cerevisiae by the immunosuppressant leflunomide is due to the inhibition of uracil uptake via Fur4p. Fujimura, H. Mol. Gen. Genet. (1998) [Pubmed]
  17. The allantoin and uracil permease gene sequences of Saccharomyces cerevisiae are nearly identical. Yoo, H.S., Cunningham, T.S., Cooper, T.G. Yeast (1992) [Pubmed]
  18. Chromosomal mapping of the uracil permease gene of Saccharomyces cerevisiae. Weber, E., Jund, R., Chevallier, M.R. Curr. Genet. (1986) [Pubmed]
  19. NH4+-induced down-regulation of the Saccharomyces cerevisiae Gap1p permease involves its ubiquitination with lysine-63-linked chains. Springael, J.Y., Galan, J.M., Haguenauer-Tsapis, R., André, B. J. Cell. Sci. (1999) [Pubmed]
  20. Deubiquitination step in the endocytic pathway of yeast plasma membrane proteins: crucial role of Doa4p ubiquitin isopeptidase. Dupré, S., Haguenauer-Tsapis, R. Mol. Cell. Biol. (2001) [Pubmed]
  21. In vivo phosphorylation of the yeast uracil permease. Volland, C., Garnier, C., Haguenauer-Tsapis, R. J. Biol. Chem. (1992) [Pubmed]
  22. Endocytosis and degradation of the yeast uracil permease under adverse conditions. Volland, C., Urban-Grimal, D., Géraud, G., Haguenauer-Tsapis, R. J. Biol. Chem. (1994) [Pubmed]
  23. Only one of the charged amino acids located in membrane-spanning regions is important for the function of the Saccharomyces cerevisiae uracil permease. Pinson, B., Chevallier, J., Urban-Grimal, D. Biochem. J. (1999) [Pubmed]
  24. The yeast plasma membrane uracil permease is stabilized against stress induced degradation by a point mutation in a cyclin-like "destruction box". Galan, J.M., Volland, C., Urban-Grimal, D., Haguenauer-Tsapis, R. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
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