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Gene Review

RGP1  -  Rgp1p

Saccharomyces cerevisiae S288c

Synonyms: Guanine nucleotide exchange factor subunit RGP1, Reduced growth phenotype protein 1, YD9302.13, YDR137W
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Disease relevance of RGP1


High impact information on RGP1

  • We have shown previously that activation of Ypt6p depends on its exchange factor, Ric1p-Rgp1p, a peripheral membrane protein complex restricted to the Golgi [2].
  • We infer that the Ric1p-Rgp1p complex serves to activate Ypt6p on Golgi membranes by nucleotide exchange, and that this is required for efficient fusion of endosome-derived vesicles with the Golgi [3].
  • Identification of Rgp1p, a novel Golgi recycling factor, as a protein required for efficient localization of yeast casein kinase 1 to the plasma membrane [4].
  • Subsequent glucosylation assays revealed that in RGP1-containing tobacco extracts as well as in RGP2-containing tobacco extracts UDP-glucose is incorporated, indicating that an RGP2-containing complex is active [1].

Other interactions of RGP1

  • Ypt6p shows a similar distribution, but this is altered when RIC1 or RGP1 is mutated [3].

Analytical, diagnostic and therapeutic context of RGP1

  • Gel filtration experiments with wheat endosperm extracts and extracts from transgenic tobacco plants, overexpressing either wheat Rgp1 or Rgp2, showed the presence of RGP1 and RGP2 in high-molecular mass complexes [1].


  1. Glucosylation activity and complex formation of two classes of reversibly glycosylated polypeptides. Langeveld, S.M., Vennik, M., Kottenhagen, M., Van Wijk, R., Buijk, A., Kijne, J.W., de Pater, S. Plant Physiol. (2002) [Pubmed]
  2. An effector of Ypt6p binds the SNARE Tlg1p and mediates selective fusion of vesicles with late Golgi membranes. Siniossoglou, S., Pelham, H.R. EMBO J. (2001) [Pubmed]
  3. Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p. Siniossoglou, S., Peak-Chew, S.Y., Pelham, H.R. EMBO J. (2000) [Pubmed]
  4. Identification of Rgp1p, a novel Golgi recycling factor, as a protein required for efficient localization of yeast casein kinase 1 to the plasma membrane. Panek, H.R., Conibear, E., Bryan, J.D., Colvin, R.T., Goshorn, C.D., Robinson, L.C. J. Cell. Sci. (2000) [Pubmed]
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