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Gene Review

RIC1  -  Ric1p

Saccharomyces cerevisiae S288c

Synonyms: Guanine nucleotide exchange factor subunit RIC1, Protein RIC1, Ribosome control protein 1, YLR039C
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High impact information on RIC1

  • We have shown previously that activation of Ypt6p depends on its exchange factor, Ric1p-Rgp1p, a peripheral membrane protein complex restricted to the Golgi [1].
  • Ric1p largely colocalizes with the late Golgi marker Sec7p [2].
  • We infer that the Ric1p-Rgp1p complex serves to activate Ypt6p on Golgi membranes by nucleotide exchange, and that this is required for efficient fusion of endosome-derived vesicles with the Golgi [2].
  • Cells carrying a deletion of RIC1 (ric1Delta) mislocalize TGN membrane proteins Kex2p and Vps10p to the vacuole [3].
  • Ric1p and the Ypt6p GTPase function in a common pathway required for localization of trans-Golgi network membrane proteins [3].

Biological context of RIC1


Anatomical context of RIC1


Other interactions of RIC1

  • Ypt6p shows a similar distribution, but this is altered when RIC1 or RGP1 is mutated [2].
  • Like rcy1Delta, cells lacking the Rab-GTPase Ypt6p or its heterodimeric GEFs Rgp1p and Ric1p are unable to recycle the v-SNARE Snc1p [5].


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