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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HST4  -  Hst4p

Saccharomyces cerevisiae S288c

Synonyms: Homologous to SIR2 protein 4, NAD-dependent histone deacetylase HST4, Regulatory protein SIR2 homolog 4, YD9346.03, YDR191W
 
 
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High impact information on HST4

  • In addition, HST3 and HST4 together contribute to proper cell cycle progression, radiation resistance, and genomic stability, establishing new connections between silencing and these fundamental cellular processes [1].
  • Consistent with a role in chromatin structure, Hst4p localizes to the nucleus and appears concentrated in the nucleolus. hst4Delta mutant phenotypes, including growth and silencing phenotypes, are similar to those of the Saccharomyces cerevisiae HSTs, and at a molecular level, hst4(+) is most similar to HST4 [2].
  • The Schizosaccharomyces pombe hst4(+) gene is a SIR2 homologue with silencing and centromeric functions [2].
  • Mutant strains show decreased silencing of reporter genes at both telomeres and centromeres. hst4(+) appears to be important for centromere function as well because mutants have elevated chromosome-loss rates and are sensitive to a microtubule-destabilizing drug [2].
  • Taking it off: regulation of H3 K56 acetylation by Hst3 and Hst4 [3].
 

Biological context of HST4

References

  1. The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Brachmann, C.B., Sherman, J.M., Devine, S.E., Cameron, E.E., Pillus, L., Boeke, J.D. Genes Dev. (1995) [Pubmed]
  2. The Schizosaccharomyces pombe hst4(+) gene is a SIR2 homologue with silencing and centromeric functions. Freeman-Cook, L.L., Sherman, J.M., Brachmann, C.B., Allshire, R.C., Boeke, J.D., Pillus, L. Mol. Biol. Cell (1999) [Pubmed]
  3. Taking it off: regulation of H3 K56 acetylation by Hst3 and Hst4. Miller, K.M., Maas, N.L., Toczyski, D.P. Cell Cycle (2006) [Pubmed]
  4. Histone H3 lysine 56 acetylation: a new twist in the chromosome cycle. Ozdemir, A., Masumoto, H., Fitzjohn, P., Verreault, A., Logie, C. Cell Cycle (2006) [Pubmed]
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