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Gene Review:

MSW1 - tryptophan--tRNA ligase MSW1

Saccharomyces cerevisiae S288c

Synonyms: D9954.7, MSW, TrpRS, Tryptophan--tRNA ligase, mitochondrial, Tryptophanyl-tRNA synthetase, ...

Jorgensen, R. et al., Schmitz, U.K. et al., Myers, A.M. et al., Entrup, R. et al., Rogers, M.J. et al.

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Disease relevance of MSW1

As the use of the UGA codon as tryptophan in mycoplasma and in yeast mitochondria is conserved, recognition of the UCA anticodon by TrpRS may also be maintained in evolution [1].

High impact information on MSW1

We conclude that the processing enzyme in plant mitochondria may recognize a proximate or even the same cleavage site within the mitochondrial tryptophanyl-tRNA-synthetase presequence as the matrix protease from yeast [2].
The deduced amino acid sequence shows high homology to both the mitochondrial tryptophanyl-tRNA synthetase ((mt)TrpRS) from Saccharomyces cerevisiae and to different eubacterial forms of tryptophanyl-tRNA synthetase (TrpRS) [3].
The wild type gene MSW capable of complementing the protein synthesis defect has been cloned by transformation of one of the mutants with a genomic library of wild type yeast nuclear DNA [4].
The mutational effect of the observed amino-acid substitution in ts2281 is discussed in terms of weakened hydrogen bonding in the C-terminal half of the MSW1-encoded protein [5].

References

Switching tRNA(Gln) identity from glutamine to tryptophan. Rogers, M.J., Adachi, T., Inokuchi, H., Söll, D. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
A yeast mitochondrial presequence functions as a signal for targeting to plant mitochondria in vivo. Schmitz, U.K., Lonsdale, D.M. Plant Cell (1989) [Pubmed]
Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase. Jorgensen, R., Søgaard, T.M., Rossing, A.B., Martensen, P.M., Justesen, J. J. Biol. Chem. (2000) [Pubmed]
MSW, a yeast gene coding for mitochondrial tryptophanyl-tRNA synthetase. Myers, A.M., Tzagoloff, A. J. Biol. Chem. (1985) [Pubmed]
An yeast nuclear mutation conferring temperature-sensitivity to the mitochondrial tryptophanyl-tRNA synthetase. Entrup, R., Langgut, W., Lisowsky, T., Schweizer, E. Curr. Genet. (1992) [Pubmed]

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AgaP_AGAP011744	Anopheles gambiae str. PEST
OVA4	Arabidopsis thaliana
AGOS_ACR089C	Ashbya gossypii ATCC 10895
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prx-10	Caenorhabditis elegans
WARS2	Canis lupus familiaris
wars2	Danio rerio
CG7441	Drosophila melanogaster
WARS2	Gallus gallus
WARS2	Homo sapiens
KLLA0E21825g	Kluyveromyces lactis NRRL Y-1140
WARS2	Macaca mulatta
MGG_14679	Magnaporthe oryzae 70-15
Wars2	Mus musculus
Os01g0743400	Oryza sativa Japonica Group
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Wars2	Rattus norvegicus
msw1	Schizosaccharomyces pombe 972h-
wars2	Xenopus (Silurana) tropicalis

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