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Wars2  -  tryptophanyl tRNA synthetase 2...

Mus musculus

Synonyms: (Mt)TrpRS, 5730427B17Rik, 9430020O07Rik, AI413375, TrpRS, ...
 
 
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Disease relevance of Wars2

  • LysRS and TrpRS are present in HIV-1 and RSV at approximately 25 and 12 molecules/virion, respectively [1].
  • The pivotal role of TrpRS in protecting against neurodegeneration is suggested, providing an insight into the pathogenesis and a possible treatment of neurodegenerative diseases [2].
 

High impact information on Wars2

  • Tryptophanyl-tRNA synthetase (TrpRS) is an interferon-induced phosphoprotein with autoantigenic and cytokine activities detected in addition to its canonical function in tRNA aminoacylation [3].
  • Here it is shown that expression of cytoplasmic-TrpRS is inversely correlated with neurofibrillary degeneration, whereas a nonionic detergent-insoluble presumably aggregated TrpRS is simultaneously accumulated in human cells treated by tryptamine, a metabolic tryptophan analog that acts as a competitive inhibitor of TrpRS [2].
  • Tryptophan-dependent tRNAtrp aminoacylation catalyzed by TrpRS can be inhibited by its substrate tryptophan at physiological concentrations was demonstrated [2].
 

Analytical, diagnostic and therapeutic context of Wars2

  • In immunoblotting, the 6C10 mAb reacts preferably with (i) oligomer than monomer, and (ii) bound than free TrpRS forms [3].

References

  1. Retrovirus-specific packaging of aminoacyl-tRNA synthetases with cognate primer tRNAs. Cen, S., Javanbakht, H., Kim, S., Shiba, K., Craven, R., Rein, A., Ewalt, K., Schimmel, P., Musier-Forsyth, K., Kleiman, L. J. Virol. (2002) [Pubmed]
  2. Tryptamine Induces Tryptophanyl-tRNA Synthetase-Mediated Neurodegeneration With Neurofibrillary Tangles in Human Cell and Mouse Models. Paley, E.L., Denisova, G., Sokolova, O., Posternak, N., Wang, X., Brownell, A.L. Neuromolecular Med. (2007) [Pubmed]
  3. Mapping and molecular characterization of novel monoclonal antibodies to conformational epitopes on NH2 and COOH termini of mammalian tryptophanyl-tRNA synthetase reveal link of the epitopes to aggregation and Alzheimer's disease. Paley, E.L., Smelyanski, L., Malinovskii, V., Subbarayan, P.R., Berdichevsky, Y., Posternak, N., Gershoni, J.M., Sokolova, O., Denisova, G. Mol. Immunol. (2007) [Pubmed]
 
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