Disease relevance of SVF1

• Hypersensitivity to oxidative stress can be reversed by treatment with the antioxidant N-acetylcysteine or expression of exogenous SVF1, although exogenous expression of Bcl-x(L) did not protect cells from cold stress [1].

High impact information on SVF1

• One of these uncharacterized genes, SVF1, promotes cell survival in mammalian cells in response to multiple apoptotic stimuli [2].
• Loss of YPK1 together with disruption of either SVF1 or SUR2 is lethal [3].
• This subset is implicated in cellular responses to stress, as loss of SVF1 is associated with defects in the diauxic shift and the oxidative stress response [3].
• Here we demonstrate a novel function for the survival factor Svf1p in the yeast sphingolipid pathway and provide evidence that Svf1p regulates the generation of a specific subset of phytosphingosine [3].
• Exogenous SVF1 expression in mammalian cells confers resistance to H(2)O(2) exposure [1].

References