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Gene Review

HPT1  -  hypoxanthine phosphoribosyltransferase

Saccharomyces cerevisiae S288c

Synonyms: BRA6, Bypass of repression by adenine protein 6, D9509.18, HGPRT, HGPRTase, ...
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High impact information on HPT1

  • The behavior of adenine auxotrophs bearing additional mutations in purine salvage pathway genes (ade apt1, ade aah1 apt1, ade hpt1) supports a model in which secretion of degradation products, uptake, and reutilization of these products is a signal between cells synchronizing the sporulation process [1].
  • Second, overexpression of HPT1 allows suppression of the deregulated phenotype of the guk1 mutants [2].
  • Ade4-su, a prototrophic allele of ade4 with reduced activity of PRPPAT, is epistatic to hpt1, suppressing purine excretion and resistance to azaadenine but not resistance to azaguanine [3].
  • Hpt1 complements and is not closely linked to the purine excreting mutants pur1 to pur5 [3].
  • Xanthine allows both genotypes to grow in the presence of MPA whereas guanine only allows growth of hpt1+ [3].

Associations of HPT1 with chemical compounds


Other interactions of HPT1

  • Mutants deficient in adenine aminohydrolase (EC 3,5,4,2) activity, aah1, and hypoxanthine:guanine phosphoribosyltransferase (EC 2,4,2,8) activity, hpt1, were used to synthesize the genotypes apt1 hpt1 aah+ and apt1 hpt+ aah1 [4].


  1. Evidence for cooperation between cells during sporulation of the yeast Saccharomyces cerevisiae. Jakubowski, H., Goldman, E. Mol. Cell. Biol. (1988) [Pubmed]
  2. Yeast GMP kinase mutants constitutively express AMP biosynthesis genes by phenocopying a hypoxanthine-guanine phosphoribosyltransferase defect. Lecoq, K., Konrad, M., Daignan-Fornier, B. Genetics (2000) [Pubmed]
  3. Hypoxanthine: guanine phosphoribosyltransferase mutants in Saccharomyces cerevisiae. Woods, R.A., Roberts, D.G., Friedman, T., Jolly, D., Filpula, D. Mol. Gen. Genet. (1983) [Pubmed]
  4. Adenine phosphoribosyltransferase mutants in Saccharomyces cerevisiae. Woods, R.A., Roberts, D.G., Stein, D.S., Filpula, D. J. Gen. Microbiol. (1984) [Pubmed]
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