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Gene Review

GUK1  -  guanylate kinase

Saccharomyces cerevisiae S288c

Synonyms: D9461.39, GMP kinase, Guanylate kinase, YDR454C
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Disease relevance of GUK1


High impact information on GUK1


Biological context of GUK1


Anatomical context of GUK1

  • Overexpression of MSN17 increased the GDP-mannose level in a wild-type strain by about threefold, and guk1 decreased the GDP-mannose level to one-fourth, suggesting a close relationship between GTP metabolism and mannose outer chain elongation; the link is presumably provided by the process of GDP-mannose transport in the Golgi membranes [9].
  • We confirmed the ability of GK to substitute for complete cytosol by reconstitution of glycopeptide export from rat liver microsomes using highly purified recombinant GK from Saccharomyces cerevisiae [10].
  • By a yeast two-hybrid approach, we identified an interaction between the GUK domain of CASK and the C2B domain of rabphilin3a, a presynaptic protein involved in synaptic vesicle exocytosis [11].
  • MAGUK with inverted domain structure-1 (MAGI-1) is a membrane-associated protein with one guanylate kinase, six PSD-95/Dlg-A/ZO-1 (PDZ), and two WW domains and is localized at tight junctions in epithelial cells [12].

Associations of GUK1 with chemical compounds


Other interactions of GUK1


Analytical, diagnostic and therapeutic context of GUK1


  1. Cloning and expression of the essential gene for guanylate kinase from yeast. Konrad, M. J. Biol. Chem. (1992) [Pubmed]
  2. A major palmitoylated membrane protein of human erythrocytes shows homology to yeast guanylate kinase and to the product of a Drosophila tumor suppressor gene. Bryant, P.J., Woods, D.F. Cell (1992) [Pubmed]
  3. The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Woods, D.F., Bryant, P.J. Cell (1991) [Pubmed]
  4. Is the erythrocyte protein p55 a membrane-bound guanylate kinase? Goebl, M.G. Trends Biochem. Sci. (1992) [Pubmed]
  5. Structural basis for nucleotide-dependent regulation of membrane-associated guanylate kinase-like domains. Li, Y., Spangenberg, O., Paarmann, I., Konrad, M., Lavie, A. J. Biol. Chem. (2002) [Pubmed]
  6. Transcriptional regulation of the yeast gmp synthesis pathway by its end products. Escobar-Henriques, M., Daignan-Fornier, B. J. Biol. Chem. (2001) [Pubmed]
  7. Crystal structure of unligated guanylate kinase from yeast reveals GMP-induced conformational changes. Blaszczyk, J., Li, Y., Yan, H., Ji, X. J. Mol. Biol. (2001) [Pubmed]
  8. Yeast GMP kinase mutants constitutively express AMP biosynthesis genes by phenocopying a hypoxanthine-guanine phosphoribosyltransferase defect. Lecoq, K., Konrad, M., Daignan-Fornier, B. Genetics (2000) [Pubmed]
  9. A defect in GTP synthesis affects mannose outer chain elongation in Saccharomyces cerevisiae. Shimma, Y., Nishikawa, A., bin Kassim, B., Eto, A., Jigami, Y. Mol. Gen. Genet. (1997) [Pubmed]
  10. A microsomal GTPase is required for glycopeptide export from the mammalian endoplasmic reticulum. Ali, B.R., Tjernberg, A., Chait, B.T., Field, M.C. J. Biol. Chem. (2000) [Pubmed]
  11. The scaffolding protein CASK mediates the interaction between rabphilin3a and beta-neurexins. Zhang, Y., Luan, Z., Liu, A., Hu, G. FEBS Lett. (2001) [Pubmed]
  12. MAGI-1 is a component of the glomerular slit diaphragm that is tightly associated with nephrin. Hirabayashi, S., Mori, H., Kansaku, A., Kurihara, H., Sakai, T., Shimizu, F., Kawachi, H., Hata, Y. Lab. Invest. (2005) [Pubmed]
  13. Structural and functional roles of tyrosine 78 of yeast guanylate kinase. Zhang, Y., Li, Y., Wu, Y., Yan, H. J. Biol. Chem. (1997) [Pubmed]
  14. Refined structure of the complex between guanylate kinase and its substrate GMP at 2.0 A resolution. Stehle, T., Schulz, G.E. J. Mol. Biol. (1992) [Pubmed]
  15. Binding of nucleotides to guanylate kinase, p21(ras), and nucleoside-diphosphate kinase studied by nano-electrospray mass spectrometry. Prinz, H., Lavie, A., Scheidig, A.J., Spangenberg, O., Konrad, M. J. Biol. Chem. (1999) [Pubmed]
  16. Guanylate kinase from Saccharomyces cerevisiae. Isolation and characterization, crystallization and preliminary X-ray analysis, amino acid sequence and comparison with adenylate kinases. Berger, A., Schiltz, E., Schulz, G.E. Eur. J. Biochem. (1989) [Pubmed]
  17. Kinetic and thermodynamic characterizations of yeast guanylate kinase. Li, Y., Zhang, Y., Yan, H. J. Biol. Chem. (1996) [Pubmed]
  18. Potential involvement of galectin-3 and SNAP23 in Aeromonas hydrophila cytotoxic enterotoxin-induced host cell apoptosis. Galindo, C.L., Gutierrez, C., Chopra, A.K. Microb. Pathog. (2006) [Pubmed]
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