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Gene Review

ADE4  -  amidophosphoribosyltransferase

Saccharomyces cerevisiae S288c

Synonyms: ATase, Amidophosphoribosyltransferase, Glutamine phosphoribosylpyrophosphate amidotransferase, YM9952.02C, YMR300C
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Disease relevance of ADE4


High impact information on ADE4

  • Consistently, both ADE4 dominant mutations and overexpression of wild-type ADE4 lead to deregulation of ADE gene expression [2].
  • Importantly, feedback inhibition by ATP of Ade4p, catalyzing the first step of the pathway, appears to regulate SAICAR synthesis in response to adenine availability [2].
  • Two GCREs are essential to synergistically activate ADE4 transcription by binding GCN4 [3].
  • The nucleotide sequence of ADE4 along with upstream and downstream flanking sequences was determined [1].
  • The ADE4 structural gene consists of 1530 base pairs from which a 510-amino acid translation product, Mr = 56,691, was deduced [1].

Chemical compound and disease context of ADE4


Biological context of ADE4


Associations of ADE4 with chemical compounds


Other interactions of ADE4

  • Furthermore, the transcription of ADE4 and SHM2 in the Deltabas1 mutant did not diminish during the transition from the trophic to the productive phase did not diminish, in contrast to what occurred in the wild-type strain [9].

Analytical, diagnostic and therapeutic context of ADE4


  1. Glutamine nucleotide sequence of Saccharomyces cerevisiae ADE4 encoding phosphoribosylpyrophosphate amidotransferase. Mäntsälä, P., Zalkin, H. J. Biol. Chem. (1984) [Pubmed]
  2. Yeast AMP pathway genes respond to adenine through regulated synthesis of a metabolic intermediate. Rébora, K., Desmoucelles, C., Borne, F., Pinson, B., Daignan-Fornier, B. Mol. Cell. Biol. (2001) [Pubmed]
  3. Transcriptional activation of yeast nucleotide biosynthetic gene ADE4 by GCN4. Mösch, H.U., Scheier, B., Lahti, R., Mäntsäla, P., Braus, G.H. J. Biol. Chem. (1991) [Pubmed]
  4. rna12+, a gene of Saccharomyces cerevisiae involved in pre-rRNA maturation. Characterization of a temperature-sensitive mutant, cloning and sequencing of the gene. Liang, S., Alksne, L., Warner, J.R., Lacroute, F. Mol. Gen. Genet. (1992) [Pubmed]
  5. Intra-chromosomal gene conversion induced by a DNA double-strand break in Saccharomyces cerevisiae. Ray, A., Siddiqi, I., Kolodkin, A.L., Stahl, F.W. J. Mol. Biol. (1988) [Pubmed]
  6. Studies on mutants affecting amidophosphoribosyltransferase activity in Saccharomyces cerevisiae. Nieto, D.J., Woods, R.A. Can. J. Microbiol. (1983) [Pubmed]
  7. Adenine phosphoribosyltransferase mutants in Saccharomyces cerevisiae. Woods, R.A., Roberts, D.G., Stein, D.S., Filpula, D. J. Gen. Microbiol. (1984) [Pubmed]
  8. Hypoxanthine: guanine phosphoribosyltransferase mutants in Saccharomyces cerevisiae. Woods, R.A., Roberts, D.G., Friedman, T., Jolly, D., Filpula, D. Mol. Gen. Genet. (1983) [Pubmed]
  9. Purine biosynthesis, riboflavin production, and trophic-phase span are controlled by a Myb-related transcription factor in the fungus Ashbya gossypii. Mateos, L., Jiménez, A., Revuelta, J.L., Santos, M.A. Appl. Environ. Microbiol. (2006) [Pubmed]
  10. Molecular cloning of rat amidophosphoribosyltransferase. Iwahana, H., Yamaoka, T., Mizutani, M., Mizusawa, N., Ii, S., Yoshimoto, K., Itakura, M. J. Biol. Chem. (1993) [Pubmed]
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