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Gene Review

VPS3  -  Vps3p

Saccharomyces cerevisiae S288c

Synonyms: D9719.1, PEP6, VPL3, VPT17, Vacuolar protein sorting-associated protein 3, ...
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High impact information on VPS3

  • Molecular analysis of the yeast VPS3 gene and the role of its product in vacuolar protein sorting and vacuolar segregation during the cell cycle [1].
  • vps3 mutants of the yeast Saccharomyces cerevisiae are impaired in the sorting of newly synthesized soluble vacuolar proteins and in the acidification of the vacuole (Rothman, J. H., and T. H. Stevens. Cell. 47:1041-1051; Rothman, J. H., C. T. Yamashiro, C. K. Raymond, P. M. Kane, and T. H. Stevens. 1989. J. Cell Biol. 109:93-100) [1].
  • With the exception of a vacuolar acidification defect, the phenotypes of vps3-delta 1 strains are significantly different from those of mutants lacking the vacuolar proton-translocating ATPase [1].
  • The acidification defect of vpl3 and vpl6 mutants correlated with a marked deficiency in vacuolar ATPase activity, diminished levels of two immunoreactive subunits of the protontranslocating ATPase (H+-ATPase) in purified vacuolar membranes, and accumulation of the intracellular portion of PrA as the precursor species [2].
  • This approach identified the VPS3, VPS8 and PEP7 genes that function in vesicular trafficking between the endosome and the yeast vacuole via the carboxypeptidase Y (CpY) pathway [3].


  1. Molecular analysis of the yeast VPS3 gene and the role of its product in vacuolar protein sorting and vacuolar segregation during the cell cycle. Raymond, C.K., O'Hara, P.J., Eichinger, G., Rothman, J.H., Stevens, T.H. J. Cell Biol. (1990) [Pubmed]
  2. Acidification of the lysosome-like vacuole and the vacuolar H+-ATPase are deficient in two yeast mutants that fail to sort vacuolar proteins. Rothman, J.H., Yamashiro, C.T., Raymond, C.K., Kane, P.M., Stevens, T.H. J. Cell Biol. (1989) [Pubmed]
  3. Overexpression of genes involved in vesicular trafficking to the vacuole defends against lethal effects of oxidative damage. Martinez, M., Pramanik, A., Moto-Ndje, S., Moore, C.W. Cell. Mol. Biol. (Noisy-le-grand) (2003) [Pubmed]
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