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Gene Review

SHP1  -  Shp1p

Saccharomyces cerevisiae S288c

Synonyms: Suppressor of high-copy PP1 protein, UBX domain-containing protein 1, UBX1, YBL0509, YBL0515, ...
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High impact information on SHP1

  • We have isolated strains which are resistant to Glc7p overproduction lethality as a result of mutations in the SHP1 (suppressor of high-copy PP1) gene, which was previously encountered in a genomic sequencing project as an open reading frame whose interruption totally blocked sporulation and slightly slowed cell proliferation [1].
  • The Saccharomyces SHP1 gene, which encodes a regulator of phosphoprotein phosphatase 1 with differential effects on glycogen metabolism, meiotic differentiation, and mitotic cell cycle progression [1].
  • These phenotypes also characterized our shp1 mutations, as did deficient glycogen accumulation [1].
  • The two major yeast UBX domain proteins, Shp1 and Ubx2, possess a ubiquitin-binding UBA domain and interact with ubiquitylated proteins in vivo [2].


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