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Gene Review

p47  -  CG11139 gene product from transcript...

Drosophila melanogaster

Synonyms: CG11139, Dmel\CG11139, anon-WO0118547.216, dp47
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High impact information on p47

  • Eyes closed, a Drosophila p47 homolog, is essential for photoreceptor morphogenesis [1].
  • Failure of this set of plasmids to support transient late gene expression, and the inability of the p47 ORF to replace the p47-containing plasmid supplied in the lef plasmid library, led to the identification of a 19th late expression factor gene (lef-12) located adjacent to the p47 gene [2].
  • Besides TER94, sex-specific forms were also detected in the gonads of the imago: p47 in the ovaries and p98 in the testis [3].
  • Previously, we reported that in clam oocytes, cytoplasmic polyadenylation element-binding protein (CPEB) co-immunoprecipitates with p47, a member of the highly conserved RCK family of RNA helicases which includes Drosophila Me31B and Saccharomyces cerevisiae Dhh1 [4].

Biological context of p47


Anatomical context of p47

  • TER94/p47 staining was observed in the nurse cells and often in the oöcytes, while TER94/p98 staining was present in the sperm bundles [3].


  1. Eyes closed, a Drosophila p47 homolog, is essential for photoreceptor morphogenesis. Sang, T.K., Ready, D.F. Development (2002) [Pubmed]
  2. Nineteen baculovirus open reading frames, including LEF-12, support late gene expression. Rapp, J.C., Wilson, J.A., Miller, L.K. J. Virol. (1998) [Pubmed]
  3. TER94, a Drosophila homolog of the membrane fusion protein CDC48/p97, is accumulated in nonproliferating cells: in the reproductive organs and in the brain of the imago. Pintér, M., Jékely, G., Szepesi, R.J., Farkas, A., Theopold, U., Meyer, H.E., Lindholm, D., Nässel, D.R., Hultmark, D., Friedrich, P. Insect Biochem. Mol. Biol. (1998) [Pubmed]
  4. The active form of Xp54 RNA helicase in translational repression is an RNA-mediated oligomer. Minshall, N., Standart, N. Nucleic Acids Res. (2004) [Pubmed]
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