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Gene Review

Nsfl1c  -  NSFL1 (p97) cofactor (p47)

Mus musculus

Synonyms: Munc-18c, NSFL1 cofactor p47, Stxbp3a, p47, p97 cofactor p47
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High impact information on Nsfl1c

  • In order to provide insight into the molecular basis of p97 adaptor binding, we have determined the crystal structure of p97 ND1 domains complexed with p47 C-terminal domain at 2.9 A resolution [1].
  • Nonhemopoietic cells accounted for the expression of STAT1-mediated indoleamine 2, 3-dioxygenase and the p47 GTPase LRG-47, but not inducible NO synthase mRNA [2].
  • The amount and subcellular distribution of syntaxin4, SNAP23, Munc-18c, and GLUT1 were unchanged in either aP2-GLUT4-/- or aP2-GLUT4-Tg adipocytes, but transferrin receptor was partially redistributed to the plasma membrane in aP2-GLUT4-Tg adipocytes [3].
  • Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases [4].

Anatomical context of Nsfl1c

  • We show that the p47 GTPases, including IIGP1, accumulate at vacuoles containing T. gondii [4].

Other interactions of Nsfl1c

  • In the latter, the p97 adaptor protein p47 is of central importance [1].


  1. Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47. Dreveny, I., Kondo, H., Uchiyama, K., Shaw, A., Zhang, X., Freemont, P.S. EMBO J. (2004) [Pubmed]
  2. STAT1 regulates IFN-alpha beta- and IFN-gamma-dependent control of infection with Chlamydia pneumoniae by nonhemopoietic cells. Rothfuchs, A.G., Trumstedt, C., Mattei, F., Schiavoni, G., Hidmark, A., Wigzell, H., Rottenberg, M.E. J. Immunol. (2006) [Pubmed]
  3. GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase. Carvalho, E., Schellhorn, S.E., Zabolotny, J.M., Martin, S., Tozzo, E., Peroni, O.D., Houseknecht, K.L., Mundt, A., James, D.E., Kahn, B.B. J. Biol. Chem. (2004) [Pubmed]
  4. Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases. Martens, S., Parvanova, I., Zerrahn, J., Griffiths, G., Schell, G., Reichmann, G., Howard, J.C. PLoS Pathog. (2005) [Pubmed]
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