Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

PTC3 - type 2C protein phosphatase PTC3

Saccharomyces cerevisiae S288c

Synonyms: PP2C-3, Protein phosphatase 2C homolog 3, YBL0511, YBL0513, YBL056W

Ruiz, A. et al., Leroy, C. et al., Warmka, J. et al., Scherens, B. et al., Young, C. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on PTC3

Cells lacking the PP2C-like phosphatases Ptc2 and Ptc3 are unable to adapt to a HO-induced DSB and are also defective in recovering from a repairable DSB [1].
Previously, multicopy expression of PTC1 and PTC3 was shown to suppress lethality of the sln1Delta strain due to hyperactivation of the HOG pathway [2].
We reported that, in the yeast Saccharomyces cerevisiae, overexpression of the Ptc3p isoform resulted in increased lithium tolerance in the hypersensitive hal3 background [3].
YBL0516 contains an intron, YBL0513 shows homology with the RAT protein phosphatase and YBL0526 contains a zinc-finger motif [4].

Associations of PTC3 with chemical compounds

In conclusion, overexpression of PTC3 and lack of PTC1 affect lithium tolerance in yeast, although through different mechanisms [3].

Other interactions of PTC3

Here, we examined the function of Ptc2 and Ptc3 [5].

References

PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break. Leroy, C., Lee, S.E., Vaze, M.B., Ochsenbien, F., Guerois, R., Haber, J.E., Marsolier-Kergoat, M.C. Mol. Cell (2003) [Pubmed]
Ptc1, a type 2C Ser/Thr phosphatase, inactivates the HOG pathway by dephosphorylating the mitogen-activated protein kinase Hog1. Warmka, J., Hanneman, J., Lee, J., Amin, D., Ota, I. Mol. Cell. Biol. (2001) [Pubmed]
Role of protein phosphatases 2C on tolerance to lithium toxicity in the yeast Saccharomyces cerevisiae. Ruiz, A., González, A., García-Salcedo, R., Ramos, J., Ariño, J. Mol. Microbiol. (2006) [Pubmed]
Sequencing and functional analysis of a 32,560 bp segment on the left arm of yeast chromosome II. Identification of 26 open reading frames, including the KIP1 and SEC17 genes. Scherens, B., el Bakkoury, M., Vierendeels, F., Dubois, E., Messenguy, F. Yeast (1993) [Pubmed]
Role of Ptc2 type 2C Ser/Thr phosphatase in yeast high-osmolarity glycerol pathway inactivation. Young, C., Mapes, J., Hanneman, J., Al-Zarban, S., Ota, I. Eukaryotic Cell (2002) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AGOS_ACR239C	Ashbya gossypii ATCC 10895
Ppm1	Drosophila melanogaster
KLLA0E19977g	Kluyveromyces lactis NRRL Y-1140
PTC2	Saccharomyces cerevisiae S288c
ptc3	Schizosaccharomyces pombe 972h-

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.