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Gene Review

PTC3  -  type 2C protein phosphatase PTC3

Saccharomyces cerevisiae S288c

Synonyms: PP2C-3, Protein phosphatase 2C homolog 3, YBL0511, YBL0513, YBL056W
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High impact information on PTC3

  • Cells lacking the PP2C-like phosphatases Ptc2 and Ptc3 are unable to adapt to a HO-induced DSB and are also defective in recovering from a repairable DSB [1].
  • Previously, multicopy expression of PTC1 and PTC3 was shown to suppress lethality of the sln1Delta strain due to hyperactivation of the HOG pathway [2].
  • We reported that, in the yeast Saccharomyces cerevisiae, overexpression of the Ptc3p isoform resulted in increased lithium tolerance in the hypersensitive hal3 background [3].
  • YBL0516 contains an intron, YBL0513 shows homology with the RAT protein phosphatase and YBL0526 contains a zinc-finger motif [4].

Associations of PTC3 with chemical compounds

  • In conclusion, overexpression of PTC3 and lack of PTC1 affect lithium tolerance in yeast, although through different mechanisms [3].

Other interactions of PTC3


  1. PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break. Leroy, C., Lee, S.E., Vaze, M.B., Ochsenbien, F., Guerois, R., Haber, J.E., Marsolier-Kergoat, M.C. Mol. Cell (2003) [Pubmed]
  2. Ptc1, a type 2C Ser/Thr phosphatase, inactivates the HOG pathway by dephosphorylating the mitogen-activated protein kinase Hog1. Warmka, J., Hanneman, J., Lee, J., Amin, D., Ota, I. Mol. Cell. Biol. (2001) [Pubmed]
  3. Role of protein phosphatases 2C on tolerance to lithium toxicity in the yeast Saccharomyces cerevisiae. Ruiz, A., González, A., García-Salcedo, R., Ramos, J., Ariño, J. Mol. Microbiol. (2006) [Pubmed]
  4. Sequencing and functional analysis of a 32,560 bp segment on the left arm of yeast chromosome II. Identification of 26 open reading frames, including the KIP1 and SEC17 genes. Scherens, B., el Bakkoury, M., Vierendeels, F., Dubois, E., Messenguy, F. Yeast (1993) [Pubmed]
  5. Role of Ptc2 type 2C Ser/Thr phosphatase in yeast high-osmolarity glycerol pathway inactivation. Young, C., Mapes, J., Hanneman, J., Al-Zarban, S., Ota, I. Eukaryotic Cell (2002) [Pubmed]
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